Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis

L. Jia, X. F. Yi, Z. B. Zhang, Z. P. Zhuang, J. Li, S. K. Chambers, B. H. Kong, W. Zheng

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The exact role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in ovarian epithelial carcinoma (OEC) development has not been yet characterized. This prompted us to identify particular proteins to better understand the underlying mechanism. Total proteins from ovarian epithelial tumor (OET) cells treated with gonadotropins were analyzed by proteomics. Western blot and immunohistochemistry were used to validate the target protein (prohibitin) and to detect its expression in human ovarian tissue of serous tumors. As the results, prohibitin was found to be significantly up-regulated by LH, with a maximum of 2.5-fold increase at the concentration of 200 mIU/mL. The expression of prohibitin was steadily decreased from benign serous cystadenomas to borderline tumors and serous carcinomas (P < 0.0001). The difference between any two groups was significant (P < 0.001). Collectively, data from this study indicate that prohibitin is one LH-associated protein and it may be protective of ovarian cancer development and progression, supporting that LH may play an inhibitory role in ovarian tumorigenesis.

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalNeoplasma
Volume58
Issue number2
DOIs
StatePublished - Jan 1 2011

Keywords

  • Gonadotropin
  • Luteinizing hormone
  • Ovarian cancer
  • Prohibitin

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis'. Together they form a unique fingerprint.

  • Cite this