Prolactin production by immune cells

Research output: Contribution to journalReview article

54 Scopus citations

Abstract

Prolactin (PRL) is a pituitary hormone and a cytokine that plays an important role in rodent and human immune responses, including autoimmune diseases. However, many cells and tissues other than the pituitary make PRL, including immune cells. Here, we will present the evidence demonstrating PRL synthesis by different subtypes of immune cells from humans, mice and rats, describe the regulation of PRL gene expression in human lymphocytes, and discuss the functions of PRL made by immune cells. Finally, we will present evidence for involvement of immune cell PRL in human autoimmune disease and suggest how it might play a unique immunoregulatory role.

Original languageEnglish (US)
Pages (from-to)665-675
Number of pages11
JournalLupus
Volume10
Issue number10
DOIs
StatePublished - Nov 20 2001
Externally publishedYes

Keywords

  • Antigen receptors
  • Autoimmunity
  • Gene expression
  • Immune response
  • Prolactin
  • Protein synthesis

ASJC Scopus subject areas

  • Rheumatology

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