Prolactin receptors on human lymphocytes and their modulation by cyclosporine

Diane Haddock Russell, Lynn Matrisian, Ruthann Kibler, Douglas F. Larson, Bonnie Poulos, Bruce E. Magun

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

Prolactin receptors have been identified for the first time on human peripheral blood lymphocytes. These receptors are present on T- and B-cells as well as monocytes. The specific binding of [125I]prolactin to these cells can be selectively enhanced at certain concentrations and blocked by higher concentrations of cyclosporine, a known immunosuppressive agent which inhibits the mitogenesis of T-cells. Prolactin also induces ornithine decarboxylase, a key growth regulatory enzyme, in lymphocytes. Therefore, we suggest that the lymphocyte prolactin receptor may be involved in regulating lymphocyte function, and that one of the actions of cyclosporine is to block this rather ubiquitously occurring receptor.

Original languageEnglish (US)
Pages (from-to)899-906
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume121
Issue number3
DOIs
StatePublished - Jun 29 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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