PROLONGATION OF POSTOPERATIVE DISEASE-FREE INTERVAL AND SURVIVAL IN HUMAN COLORECTAL CANCER BY B.C.G. OR B.C.G. PLUS 5-FLUOROURACIL

Giora M. Mavligit, Michael A. Burgess, G. Burton Seibert, Andre V. Jubert, Charles M. Mcbride, Edmund A. Gehan, Jordan U. Gutterman, Nayerh Khankhanian, John F. Speer, Richard C. Martin, Edward M. Copeland, Evan M. Hersh

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

83 patients with colorectal carcinoma of the Dukes' C class were randomised to receive postoperative adjuvant therapy with B.C.G. alone or in combination with oral doses of 5-fluorouracil (5-F.U.), and have been followed for up to thirty months. Results were compared with carefully selected historical controls who were treated by surgery alone. A statistically significant prolongation of both disease-free interval and overall survival was observed in 50 patients receiving the combination of B.C.G. and 5-F.U. (P=0·03, P=0·01 respectively) as well as in 33 patients receiving B.C.G. alone (P=0·03, P=0·05 respectively). The efficacy of B.C.G.+5-F.U. was independent of the number of tumour-involved lymph-nodes in the surgical specimen. In contrast, B.C.G. given alone appears to be highly effective among 10 patients with 6 or more positive lymph-nodes (P<0·04) and ineffective (as yet) among 23 patients with 5 or less positive lymph-nodes. These results suggest that adjuvant immunotherapy, with or without chemotherapy, can improve the prognosis of surgically treated patients with colorectal carcinoma of the Dukes' C class.

Original languageEnglish (US)
Pages (from-to)871-876
Number of pages6
JournalThe Lancet
Volume307
Issue number7965
DOIs
StatePublished - Apr 24 1976

ASJC Scopus subject areas

  • Medicine(all)

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    Mavligit, G. M., Burgess, M. A., Seibert, G. B., Jubert, A. V., Mcbride, C. M., Gehan, E. A., Gutterman, J. U., Khankhanian, N., Speer, J. F., Martin, R. C., Copeland, E. M., & Hersh, E. M. (1976). PROLONGATION OF POSTOPERATIVE DISEASE-FREE INTERVAL AND SURVIVAL IN HUMAN COLORECTAL CANCER BY B.C.G. OR B.C.G. PLUS 5-FLUOROURACIL. The Lancet, 307(7965), 871-876. https://doi.org/10.1016/S0140-6736(76)92093-6