Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm

J. P. Kemp, R. J. Dockhorn, W. W. Busse, E. R. Bleecker, A. Van As

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Physical exercise is a common trigger for bronchial asthma. We evaluated the preventive effect on exercise-induced bronchospasm (EIB) of a single 42 μg dose of salmeterol, a uniquely long-acting inhaled bronchodilator, and compared salmeterol with 180 μg albuterol in two independent, randomized, double-blind, placebo-controlled studies involving 161 subjects. Three exercise challenges were conducted over 12 h, and bronchoconstriction following the serial challenges was assessed as change in FEV1 compared with predose values. The mean maximal percentage decrease in FEV1 after the three exercise challenges was 5% at 0.5 h, 8% at 5.5 h, and 13% at 11.5 h postdose in the salmeterol group compared with 7, 25, and 27%, respectively, in the albuterol group and 27, 27, and 26%, respectively, in the placebo group (p < 0.001, overall treatment difference). Albuterol provided complete protection against EIB (defined as < 10% decrease in FEV1 compared with predose values) only after the first exercise challenge, but salmeterol continued to provide complete protection in the majority of subjects after each exercise challenge: 80% (44 of 55) at 0.5 h, 70% (37 of 53) at 5.5 h, and 55% (29 of 53) at 11.5 h. Electrocardiographic monitoring revealed no clinically significant changes in any treatment group 15 and 30 min following each exercise challenge. In summary, these data demonstrate that salmeterol is effective against EIB and that a single 42 μg dose can prevent EIB for up to 12 h.

Original languageEnglish (US)
Pages (from-to)1612-1615
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Volume150
Issue number6 I
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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