Promoting evidence-based management of anemia in cancer patients: Background, development, and scientific validation of RESPOND, a web-based clinical guidance system based on the EORTC guidelines

Matti Aapro, Joanna Van Erps, Karen MacDonald, Pierre Soubeyran, Matthew Turner, Michael Muenzberg, Robert Dunlop, Hans Warrinnier, Ivo Abraham

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The 2006 EORTC guidelines for erythropoietic proteins in cancer-related anemia provide the most up-to-date assessment of the evidence base. Considering general concerns in medicine about clinicians' adoption of evidence-based guidelines, it is critical to find ways of bringing guidelines to the point of care. We describe the rationale behind RESPOND, a web-based clinical guidance system based on the EORTC guidelines, and the methodologies of two studies conducted to validate the system. In a first descriptive study, experts are asked to rate the accuracy of every algorithm derived from the guidelines. In a second step and using a hybrid matched pre-post design, separate retrospective and prospective patient cohorts matched by type of cancer and similarity of chemotherapy regimen (33 pairs) are used to examine the extent to which clinicians' practice patterns converge with the EORTC guidelines when they use or not use the RESPOND system. It is hypothesized that these studies will provide the necessary validation for RESPOND as an evidence-based clinical support tool.

Original languageEnglish (US)
Pages (from-to)32-42
Number of pages11
JournalCritical Reviews in Oncology/Hematology
Volume65
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Anemia
  • Cancer
  • Decision-support systems
  • Erythropoietic proteins
  • Treatment guidelines
  • Validation

ASJC Scopus subject areas

  • Hematology
  • Oncology

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