Properties and biological activities of thioredoxins

G. Powis, W. R. Montfort

Research output: Contribution to journalReview article

259 Scopus citations

Abstract

The mammalian thioredoxins are a family of small (approximately 12 kDa) redox proteins that undergo NADPH-dependent reduction by thioredoxin reductase and in turn reduce oxidized cysteine groups on proteins. The two main thioredoxins are thioredoxin-1, a cytosolic and nuclear form, and thioredoxin-2, a mitochondrial form. Thioredoxin-1 has been studied more. It performs many biological actions including the supply of reducing equivalents to thioredoxin peroxidases and ribonucleotide reductase, the regulation of transcription factor activity, and the regulation of enzyme activity by heterodimer formation. Thioredoxin-1 stimulates cell growth and is an inhibitor of apoptosis. Thioredoxins may play a role in a variety of human diseases including cancer. An increased level of thioredoxin-1 is found in many human tumors, where it is associated with aggressive tumor growth. Drugs are being developed that inhibit thioredoxin and that have antitumor activity.

Original languageEnglish (US)
Pages (from-to)421-455
Number of pages35
JournalAnnual Review of Biophysics and Biomolecular Structure
Volume30
DOIs
StatePublished - 2001

Keywords

  • Thioredoxin reductase
  • Thioredoxin-1
  • Thioredoxin-2

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

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