Prophylactic cranial irradiation for limited non-small cell lung cancer

B. R. Griffin, Robert B Livingston, G. R. Stewart, C. Higano, K. J. Russell, T. W. Griffin, G. E. Laramore

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seventy-three patients with biopsy-proven limited non-small cell lung cancer (NSCLC) were entered on a combined modality study at the University of Washington. Seventy-five percent (55 of 73) of the patients had a histologyc diagnosis of adenocarcinoma or large cell carcinoma, whereas 25% (18 of 73) had squamous cell carcinoma. After two cycles of chemotherapy, patients without evidence of progressive disease received prophylactic cranial irradiation (PCI) and chest radiotherapy, followed by two additional cycles of chemotherapy. Brain computed tomography (CT) scans were performed at 3-month intervals after completion of therapy in all patients, and were additionally performed whenever signs or symptoms developed suggesting neurologic dysfunction or recurrent brain disease. Sixty-five patients were treated with PCI. No clinical or CT evidence of recurrence in the brain has developed in patients who completed PCI. PCI appears to be effective in greatly reducing the incidence of brain relapse in patients with limited NSCLC.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalCancer
Volume62
Issue number1
StatePublished - 1988
Externally publishedYes

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Cranial Irradiation
Non-Small Cell Lung Carcinoma
Brain
Tomography
Large Cell Carcinoma
Recurrence
Drug Therapy
Brain Diseases
Neurologic Manifestations
Signs and Symptoms
Squamous Cell Carcinoma
Adenocarcinoma
Radiotherapy
Thorax
Biopsy
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Griffin, B. R., Livingston, R. B., Stewart, G. R., Higano, C., Russell, K. J., Griffin, T. W., & Laramore, G. E. (1988). Prophylactic cranial irradiation for limited non-small cell lung cancer. Cancer, 62(1), 36-39.

Prophylactic cranial irradiation for limited non-small cell lung cancer. / Griffin, B. R.; Livingston, Robert B; Stewart, G. R.; Higano, C.; Russell, K. J.; Griffin, T. W.; Laramore, G. E.

In: Cancer, Vol. 62, No. 1, 1988, p. 36-39.

Research output: Contribution to journalArticle

Griffin, BR, Livingston, RB, Stewart, GR, Higano, C, Russell, KJ, Griffin, TW & Laramore, GE 1988, 'Prophylactic cranial irradiation for limited non-small cell lung cancer', Cancer, vol. 62, no. 1, pp. 36-39.
Griffin BR, Livingston RB, Stewart GR, Higano C, Russell KJ, Griffin TW et al. Prophylactic cranial irradiation for limited non-small cell lung cancer. Cancer. 1988;62(1):36-39.
Griffin, B. R. ; Livingston, Robert B ; Stewart, G. R. ; Higano, C. ; Russell, K. J. ; Griffin, T. W. ; Laramore, G. E. / Prophylactic cranial irradiation for limited non-small cell lung cancer. In: Cancer. 1988 ; Vol. 62, No. 1. pp. 36-39.
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