Prophylaxis and treatment of experimental lung metastases in mice after treatment with liposome-encapsulated 6-O-stearoyl-N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine

Gabriel Lopez-Berestein, Luka Milas, Nancy Hunter, Kapil Mehta, Evan M Hersh, Carol G. Kurahara, Marjorie Vanderpas, Deborah A. Eppstein

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A new lipophilic muramyl dipeptide analog, 6-O-stearoyl-N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine, when incorporated in liposomes, was effective in both the prevention and eradication of experimental pulmonary metastases in mice. Multilamellar vesicles composed of synthetic phospholipids (phosphatidylglycerol and phosphatidylcholine) containing saturated myristoyl or unsaturated dioleoyl acyl chains were found to potentiate the antimetastatic activity of this glycopeptide. Prophylactic and therapeutic efficacy was observed against the three murine tumors tested: FSa, an immunogenic fibrosarcoma; NFSa, a nonimmunogenic fibrosarcoma; and B16 melanoma. Neither the administration of empty liposomes or free glycopeptide, nor their coadministration, had a significant antimetastatic effect. This approach is promising for the therapy of cancer metastases in humans, particularly in the prevention of metastatic seeding and in the treatment of micrometastases.

Original languageEnglish (US)
Pages (from-to)127-137
Number of pages11
JournalClinical and Experimental Metastasis
Volume2
Issue number2
DOIs
StatePublished - Apr 1984
Externally publishedYes

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Liposomes
Glycopeptides
Fibrosarcoma
Neoplasm Metastasis
Lung
Neoplasm Micrometastasis
Phosphatidylglycerols
Experimental Melanomas
Phosphatidylcholines
Neoplasms
Phospholipids
Therapeutics
isoglutamine
6-O-stearoyl-N-acetylmuramyl-alanylisoglutamine

ASJC Scopus subject areas

  • Cancer Research

Cite this

Prophylaxis and treatment of experimental lung metastases in mice after treatment with liposome-encapsulated 6-O-stearoyl-N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine. / Lopez-Berestein, Gabriel; Milas, Luka; Hunter, Nancy; Mehta, Kapil; Hersh, Evan M; Kurahara, Carol G.; Vanderpas, Marjorie; Eppstein, Deborah A.

In: Clinical and Experimental Metastasis, Vol. 2, No. 2, 04.1984, p. 127-137.

Research output: Contribution to journalArticle

Lopez-Berestein, Gabriel ; Milas, Luka ; Hunter, Nancy ; Mehta, Kapil ; Hersh, Evan M ; Kurahara, Carol G. ; Vanderpas, Marjorie ; Eppstein, Deborah A. / Prophylaxis and treatment of experimental lung metastases in mice after treatment with liposome-encapsulated 6-O-stearoyl-N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine. In: Clinical and Experimental Metastasis. 1984 ; Vol. 2, No. 2. pp. 127-137.
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abstract = "A new lipophilic muramyl dipeptide analog, 6-O-stearoyl-N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine, when incorporated in liposomes, was effective in both the prevention and eradication of experimental pulmonary metastases in mice. Multilamellar vesicles composed of synthetic phospholipids (phosphatidylglycerol and phosphatidylcholine) containing saturated myristoyl or unsaturated dioleoyl acyl chains were found to potentiate the antimetastatic activity of this glycopeptide. Prophylactic and therapeutic efficacy was observed against the three murine tumors tested: FSa, an immunogenic fibrosarcoma; NFSa, a nonimmunogenic fibrosarcoma; and B16 melanoma. Neither the administration of empty liposomes or free glycopeptide, nor their coadministration, had a significant antimetastatic effect. This approach is promising for the therapy of cancer metastases in humans, particularly in the prevention of metastatic seeding and in the treatment of micrometastases.",
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