Propylene glycol-induced proximal renal tubular cell injury

Peter D. Yorgin, Andreas A Theodorou, Amira Al-Uzri, Karen Davenport, Leslie V Boyer, Mary I. Johnson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. Although uncommon, acute renal failure has been attributed to propylene glycol. The mechanism of propylene glycol-mediated renal injury is unknown. We report a case of acute renal failure in a 16- year-old boy given large doses of pentobarbital and phenobarbital, both of which are solubilized with propylene glycol. A renal biopsy showed proximal renal tubular cell swelling and vacuole formation. The data from this case suggest that the reversible acute renal failure caused by propylene glycol is attributable to proximal renal tubular cell injury.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume30
Issue number1
StatePublished - Jul 1997

Fingerprint

Propylene Glycol
Kidney
Acute Kidney Injury
Wounds and Injuries
Pentobarbital
Phenobarbital
Vacuoles
Biopsy
Injections

Keywords

  • 1,2 propandiol
  • Acute renal failure
  • Hyperosmolarity
  • Lactic acidosis
  • Osmotic nephrosis
  • Propylene glycol

ASJC Scopus subject areas

  • Nephrology

Cite this

Yorgin, P. D., Theodorou, A. A., Al-Uzri, A., Davenport, K., Boyer, L. V., & Johnson, M. I. (1997). Propylene glycol-induced proximal renal tubular cell injury. American Journal of Kidney Diseases, 30(1), 134-139.

Propylene glycol-induced proximal renal tubular cell injury. / Yorgin, Peter D.; Theodorou, Andreas A; Al-Uzri, Amira; Davenport, Karen; Boyer, Leslie V; Johnson, Mary I.

In: American Journal of Kidney Diseases, Vol. 30, No. 1, 07.1997, p. 134-139.

Research output: Contribution to journalArticle

Yorgin, PD, Theodorou, AA, Al-Uzri, A, Davenport, K, Boyer, LV & Johnson, MI 1997, 'Propylene glycol-induced proximal renal tubular cell injury', American Journal of Kidney Diseases, vol. 30, no. 1, pp. 134-139.
Yorgin, Peter D. ; Theodorou, Andreas A ; Al-Uzri, Amira ; Davenport, Karen ; Boyer, Leslie V ; Johnson, Mary I. / Propylene glycol-induced proximal renal tubular cell injury. In: American Journal of Kidney Diseases. 1997 ; Vol. 30, No. 1. pp. 134-139.
@article{9d3cacaf98ca4e069dff4018174343a5,
title = "Propylene glycol-induced proximal renal tubular cell injury",
abstract = "Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. Although uncommon, acute renal failure has been attributed to propylene glycol. The mechanism of propylene glycol-mediated renal injury is unknown. We report a case of acute renal failure in a 16- year-old boy given large doses of pentobarbital and phenobarbital, both of which are solubilized with propylene glycol. A renal biopsy showed proximal renal tubular cell swelling and vacuole formation. The data from this case suggest that the reversible acute renal failure caused by propylene glycol is attributable to proximal renal tubular cell injury.",
keywords = "1,2 propandiol, Acute renal failure, Hyperosmolarity, Lactic acidosis, Osmotic nephrosis, Propylene glycol",
author = "Yorgin, {Peter D.} and Theodorou, {Andreas A} and Amira Al-Uzri and Karen Davenport and Boyer, {Leslie V} and Johnson, {Mary I.}",
year = "1997",
month = "7",
language = "English (US)",
volume = "30",
pages = "134--139",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Propylene glycol-induced proximal renal tubular cell injury

AU - Yorgin, Peter D.

AU - Theodorou, Andreas A

AU - Al-Uzri, Amira

AU - Davenport, Karen

AU - Boyer, Leslie V

AU - Johnson, Mary I.

PY - 1997/7

Y1 - 1997/7

N2 - Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. Although uncommon, acute renal failure has been attributed to propylene glycol. The mechanism of propylene glycol-mediated renal injury is unknown. We report a case of acute renal failure in a 16- year-old boy given large doses of pentobarbital and phenobarbital, both of which are solubilized with propylene glycol. A renal biopsy showed proximal renal tubular cell swelling and vacuole formation. The data from this case suggest that the reversible acute renal failure caused by propylene glycol is attributable to proximal renal tubular cell injury.

AB - Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. Although uncommon, acute renal failure has been attributed to propylene glycol. The mechanism of propylene glycol-mediated renal injury is unknown. We report a case of acute renal failure in a 16- year-old boy given large doses of pentobarbital and phenobarbital, both of which are solubilized with propylene glycol. A renal biopsy showed proximal renal tubular cell swelling and vacuole formation. The data from this case suggest that the reversible acute renal failure caused by propylene glycol is attributable to proximal renal tubular cell injury.

KW - 1,2 propandiol

KW - Acute renal failure

KW - Hyperosmolarity

KW - Lactic acidosis

KW - Osmotic nephrosis

KW - Propylene glycol

UR - http://www.scopus.com/inward/record.url?scp=0030835445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030835445&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 134

EP - 139

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 1

ER -