Prospective study of leukocyte count as a predictor of incident breast, colorectal, endometrial, and lung cancer and mortality in postmenopausal women

Karen L. Margolis, Rebecca J. Rodabough, Cynthia Thomson, Ana Maria Lopez, Anne McTiernan

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: The immune system and inflammation are implicated in the pathogenesis of cancer. Prospective studies linking biomarkers of inflammation with cancer incidence and mortality have been inconclusive. Methods: To determine whether there is an independent association of white blood cell (WBC) count with incident cancer in postmenopausal women, a prospective cohort study was performed at 40 US clinical centers involving 143 748 postmenopausal women aged 50 to 79 years who were free of cancer at baseline and were enrolled in the Women's Health Initiative. The main outcome measures were incident invasive breast, colorectal, endometrial, and lung cancer. Results: In multivariate models, there was a graded association of WBC count with incidence of all 4 types of cancer. Compared with the lowest quartile of WBC count (2.50-4.79×109 cells/L), women with a WBC count in the upper quartile (6.80-15.00×109 cells/L) had a statistically significantly higher risk of invasive breast cancer (hazard ratio [HR], 1.15; 95% confidence interval [CI], 1.04-1.26), colorectal cancer (HR, 1.19; 95% CI, 1.00-1.41), endometrial cancer (HR, 1.42; 95% CI, 1.12-1.79), and lung cancer (HR, 1.63; 95% CI, 1.35-1.97). The findings were similar when cancers that occurred during the first 2 years of follow-up were excluded. Statistically significant associations remained for invasive breast cancer and endometrial cancer when the analyses were limited to nonsmokers. The WBC count was also statistically significantly associated with breast cancer, lung cancer, and overall cancer mortality. Conclusion: Postmenopausal women with higher WBC counts have a higher risk of incident invasive breast, colorectal, endometrial, and lung cancer, as well as a higher risk of breast, lung, and overall cancer mortality.

Original languageEnglish (US)
Pages (from-to)1837-1844
Number of pages8
JournalArchives of Internal Medicine
Volume167
Issue number17
DOIs
StatePublished - Sep 24 2007

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Endometrial Neoplasms
Leukocyte Count
Colorectal Neoplasms
Lung Neoplasms
Prospective Studies
Breast Neoplasms
Mortality
Neoplasms
Confidence Intervals
Inflammation
Incidence
Women's Health
Immune System
Breast
Cohort Studies
Biomarkers
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Internal Medicine

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Prospective study of leukocyte count as a predictor of incident breast, colorectal, endometrial, and lung cancer and mortality in postmenopausal women. / Margolis, Karen L.; Rodabough, Rebecca J.; Thomson, Cynthia; Lopez, Ana Maria; McTiernan, Anne.

In: Archives of Internal Medicine, Vol. 167, No. 17, 24.09.2007, p. 1837-1844.

Research output: Contribution to journalArticle

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abstract = "Background: The immune system and inflammation are implicated in the pathogenesis of cancer. Prospective studies linking biomarkers of inflammation with cancer incidence and mortality have been inconclusive. Methods: To determine whether there is an independent association of white blood cell (WBC) count with incident cancer in postmenopausal women, a prospective cohort study was performed at 40 US clinical centers involving 143 748 postmenopausal women aged 50 to 79 years who were free of cancer at baseline and were enrolled in the Women's Health Initiative. The main outcome measures were incident invasive breast, colorectal, endometrial, and lung cancer. Results: In multivariate models, there was a graded association of WBC count with incidence of all 4 types of cancer. Compared with the lowest quartile of WBC count (2.50-4.79×109 cells/L), women with a WBC count in the upper quartile (6.80-15.00×109 cells/L) had a statistically significantly higher risk of invasive breast cancer (hazard ratio [HR], 1.15; 95{\%} confidence interval [CI], 1.04-1.26), colorectal cancer (HR, 1.19; 95{\%} CI, 1.00-1.41), endometrial cancer (HR, 1.42; 95{\%} CI, 1.12-1.79), and lung cancer (HR, 1.63; 95{\%} CI, 1.35-1.97). The findings were similar when cancers that occurred during the first 2 years of follow-up were excluded. Statistically significant associations remained for invasive breast cancer and endometrial cancer when the analyses were limited to nonsmokers. The WBC count was also statistically significantly associated with breast cancer, lung cancer, and overall cancer mortality. Conclusion: Postmenopausal women with higher WBC counts have a higher risk of incident invasive breast, colorectal, endometrial, and lung cancer, as well as a higher risk of breast, lung, and overall cancer mortality.",
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AB - Background: The immune system and inflammation are implicated in the pathogenesis of cancer. Prospective studies linking biomarkers of inflammation with cancer incidence and mortality have been inconclusive. Methods: To determine whether there is an independent association of white blood cell (WBC) count with incident cancer in postmenopausal women, a prospective cohort study was performed at 40 US clinical centers involving 143 748 postmenopausal women aged 50 to 79 years who were free of cancer at baseline and were enrolled in the Women's Health Initiative. The main outcome measures were incident invasive breast, colorectal, endometrial, and lung cancer. Results: In multivariate models, there was a graded association of WBC count with incidence of all 4 types of cancer. Compared with the lowest quartile of WBC count (2.50-4.79×109 cells/L), women with a WBC count in the upper quartile (6.80-15.00×109 cells/L) had a statistically significantly higher risk of invasive breast cancer (hazard ratio [HR], 1.15; 95% confidence interval [CI], 1.04-1.26), colorectal cancer (HR, 1.19; 95% CI, 1.00-1.41), endometrial cancer (HR, 1.42; 95% CI, 1.12-1.79), and lung cancer (HR, 1.63; 95% CI, 1.35-1.97). The findings were similar when cancers that occurred during the first 2 years of follow-up were excluded. Statistically significant associations remained for invasive breast cancer and endometrial cancer when the analyses were limited to nonsmokers. The WBC count was also statistically significantly associated with breast cancer, lung cancer, and overall cancer mortality. Conclusion: Postmenopausal women with higher WBC counts have a higher risk of incident invasive breast, colorectal, endometrial, and lung cancer, as well as a higher risk of breast, lung, and overall cancer mortality.

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