Prospective three-dimensional analysis of structure and function in vitreomacular adhesion cured by pharmacologic vitreolysis

Kevin R. Tozer, Wolfgang Fink, Alfredo A. Sadun, Jerry Sebag

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Purpose: To prospectively characterize macular structure and function as assessed by combined three-dimensional spectral-domain optical coherence tomography and scanning laser ophthalmoscopy and 3D computer-automated threshold Amsler grid, respectively, in a patient undergoing pharmacologic vitreolysis for vitreomacular adhesion with tractional cysts. Methods: Combined 3D optical coherence tomography and scanning laser ophthalmoscopy measured macular volume and 3D computer-automated threshold Amsler grid quantified central visual field function by determining the absolute percent magnitude lost (cumulative value of total visual field loss over all tested levels) before and for a period of 6 months after pharmacologic vitreolysis for vitreomacular adhesion with a single intravitreal injection of microplasmin (125 mg; ThromboGenics). Results: Ocriplasmin pharmacologic vitreolysis released vitreomacular adhesion by 2 weeks and decreased macular volume from 0.32 mL to 0.15 mL by 1 year after injection. There was a concomitant 4-fold improvement in visual function as measured by 3D computer-automated threshold Amsler grid (percent of central visual field lost) and Snellen visual acuity improved from 20/200 to 20/40. Conclusion: For assessing macular function improvement in conjunction with structural reintegration after pharmacologic vitreolysis for vitreomacular adhesion, 3D computerautomated threshold Amsler grid is a useful tool. Both 3D measurements quantitatively characterized the resolution of this patient's vitreomacular adhesion, suggesting that this is a useful approach to quantifying macular structure and function as indices of the severity of disease and the response to therapy.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalRetinal Cases and Brief Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2013

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Keywords

  • Central vision
  • Combined OCT/SLO imaging
  • Contrast-sensitive threshold Amsler grid
  • Macular hole
  • Pharmacologic vitreolysis
  • Vitreous

ASJC Scopus subject areas

  • Ophthalmology

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