Prospects for xenotransplantation of the liver

Robert C. Harland, Jeffrey L. Platt

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A severe shortage of human livers for allotransplantation has sparked interest in the potential use of animals in lieu of humans as a source of livers, that is xenotransplantation. Xenotransplantation might also provide a means by which recurrence of hepatitis might be averted. Among the types of xenografts that might be undertaken are extracorporeal "xenoperfusion" or perfusion of devices containing xenogeneic hepatocytes, auxiliary liver transplants, bridge liver transplants, and hepatocyte transplants. The hurdles to xenotransplantation of the liver include the immune response of the recipient against the graft, incompatibility of the graft with complex physiologic and biochemical systems of the recipient, and the possibility of transferring infectious agent from the graft to the recipient. Recent progress in characterizing and overcoming these hurdles has encouraged some optimism regarding the ultimate application of xenotransplantation for the treatment of human disease.

Original languageEnglish (US)
Pages (from-to)511-522
Number of pages12
JournalSeminars in Liver Disease
Volume20
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Immunology
  • Liver
  • Xenotransplantation

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Prospects for xenotransplantation of the liver'. Together they form a unique fingerprint.

Cite this