Prostacyclin infusion in acute cerebral infarction

V. T. Miller, Bruce M Coull, F. M. Yatsu, A. B. Shah, N. B. Beamer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We gave prostacyclin infusions to seven patients with acute cerebral infarction. Patients without CT evidence of infarction improved, but those who already had hypodensities on CT did not benefit. Increased platelet activity, measured by plasma beta-thromboglobulin, decreased significantly (p < 0.01) during prostacyclin administration to normal levels, but rose again after the infusion. These results indicate that prostacyclin can be given safely in doses adequate to suppress platelet function. Our findings encouraged us to proceed with a controlled trial of its clinical efficacy.

Original languageEnglish (US)
Pages (from-to)1431-1435
Number of pages5
JournalNeurology
Volume34
Issue number11
StatePublished - 1984
Externally publishedYes

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Cerebral Infarction
Epoprostenol
Blood Platelets
beta-Thromboglobulin
Infarction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Miller, V. T., Coull, B. M., Yatsu, F. M., Shah, A. B., & Beamer, N. B. (1984). Prostacyclin infusion in acute cerebral infarction. Neurology, 34(11), 1431-1435.

Prostacyclin infusion in acute cerebral infarction. / Miller, V. T.; Coull, Bruce M; Yatsu, F. M.; Shah, A. B.; Beamer, N. B.

In: Neurology, Vol. 34, No. 11, 1984, p. 1431-1435.

Research output: Contribution to journalArticle

Miller, VT, Coull, BM, Yatsu, FM, Shah, AB & Beamer, NB 1984, 'Prostacyclin infusion in acute cerebral infarction', Neurology, vol. 34, no. 11, pp. 1431-1435.
Miller VT, Coull BM, Yatsu FM, Shah AB, Beamer NB. Prostacyclin infusion in acute cerebral infarction. Neurology. 1984;34(11):1431-1435.
Miller, V. T. ; Coull, Bruce M ; Yatsu, F. M. ; Shah, A. B. ; Beamer, N. B. / Prostacyclin infusion in acute cerebral infarction. In: Neurology. 1984 ; Vol. 34, No. 11. pp. 1431-1435.
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