Prostacyclin infusion in acute cerebral infarction

Vincent T. Miller, Bruce M. Coull, Frank M. Yatsu, Arun B. Shah, Nancy B. Beamer

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We gave prostacyclin infusions to seven patients with acute cerebral infarction. Patients without CT evidence of infarction improved, but those who already had hypodensities on CT did not benefit. Increased platelet activity, measured by plasma beta-thromboglobulin, decreased significantly (p < 0.01) during prostacyclin administration to normal levels, but rose again after the infusion. These results indicate that prostacyclin can be given safely in doses adequate to suppress platelet function. Our findings encouraged us to proceed with a controlled trial of its clinical efficacy.

Original languageEnglish (US)
Pages (from-to)1431-1435
Number of pages5
JournalNeurology
Volume34
Issue number11
DOIs
StatePublished - Nov 1984
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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    Miller, V. T., Coull, B. M., Yatsu, F. M., Shah, A. B., & Beamer, N. B. (1984). Prostacyclin infusion in acute cerebral infarction. Neurology, 34(11), 1431-1435. https://doi.org/10.1212/wnl.34.11.1431