Prostaglandin F stimulation of cyclooxygenase-2 promoter activity by the FPB prostanoid receptor

Hiromichi Fujino, John W. Regan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We have recently shown that the FPB prostanoid receptor activates β-catenin signaling through the activation of Rho in human embryo kidney (HEK)-293 cells stably expressing the FPB receptors. We now report that the FPB receptor can stimulate cyclooxygenase-2 promoter activity and may, therefore, regulate the expression of cyclooxygenase-2. This stimulation of cyclooxygenase-2 promoter activity is blocked by pretreatment with an inhibitor of Rho, but not with an inhibitor of protein kinase C (PKC). Potential up regulation of cyclooxygenase-2 expression by the FPB receptor would establish a positive feedback loop that would drive β-catenin signaling and could be involved in cancer.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalEuropean Journal of Pharmacology
Volume465
Issue number1-2
DOIs
StatePublished - Mar 28 2003

Keywords

  • Cyclooxygenase-2
  • FP prostanoid receptor
  • β-catenin signaling

ASJC Scopus subject areas

  • Pharmacology

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