Prostaglandins and the pulmonary circulation

Joseph S Alpert, Florence W. Haynes, Paul A. Knutson, James E. Dalen, Lewis Dexter

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11 Scopus citations

Abstract

Prostaglandins (PG) E1, E2, F2α, and A1 were infused into 15 normal mongrel dogs at doses varying from .04 - 6.0 μg/kg/min. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; pulmonary blood volume and cardiac output were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. PGE1 caused mild active vasodilatation while PGF2α resulted in milactive vasoconstriction in the lung. PGE2 and PGA1 caused passive shrinkage of the pulmonary vascular bed secondary to a shift of blood to the peripheral circulation.

Original languageEnglish (US)
Pages (from-to)759-765
Number of pages7
JournalProstaglandins
Volume3
Issue number6
DOIs
Publication statusPublished - 1973
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Alpert, J. S., Haynes, F. W., Knutson, P. A., Dalen, J. E., & Dexter, L. (1973). Prostaglandins and the pulmonary circulation. Prostaglandins, 3(6), 759-765. https://doi.org/10.1016/0090-6980(73)90002-6