Prostanoid receptors and phosphatidylinositol 3-kinase: A pathway to cancer?

Hiromichi Fujino, John W Regan

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

The significance of receptor heterogeneity has, in many cases, been unclear, particularly in the case of closely related receptor subtypes that are activated by the same endogenous ligands and appear to signal through the same second messenger pathways. In this article, recent studies of the EP and FP prostanoid receptors are reviewed, showing that receptor subtypes previously thought to activate the same signaling pathways, in fact, differ through novel interactions with phosphatidylinositol 3-kinase and activation of nuclear signaling pathways. These findings might be applicable to other families of G-protein-coupled receptors and have implications in cancer and other diseases.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalTrends in Pharmacological Sciences
Volume24
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

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ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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