Prostate Cancer Characteristics and Outcomes after Prostatectomy in Asian-American Men

Tanya Dorff, James Shen, Nora Ruel, Rick Kittles, Yung Lyou, Savita Dandapani, Jeff Wong, Huiqing Wu, Sumanta Pal, Clayton Lau, Bertram Yuh

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prostate cancer is the most commonly diagnosed cancer in American men, with striking differences between ethnic groups. Given the potential for lifestyle or genetic variations between subsets of Asian-American men to impact prostate cancer behavior, we sought to define the outcomes after radical prostatectomy among various Asian groups treated at an NCI-designated comprehensive cancer center. Methods: The City of Hope IRB-approved prostatectomy database was searched from 2003 to 2015 to identify Asian-American men. Clinical and pathologic features were collected and analyzed for association with biochemical recurrence-free survival and overall survival (OS). Categorical data were evaluated using χ2and Fisher's exact tests. Survival curves were compared between groups using log-rank testing. Results: Three hundred and eighty-three Asian-American men were included in the dataset. While Asian men as a group had lower BMI than African-American and white men in the database, there was a wide range between ethnic sub-groups. Chinese men more commonly presented with D'Amico low risk disease features (P= .04) compared to other Asian men. Pacific Islander men had the lowest rate of ≥T3 stage and the highest biochemical recurrence-free survival. OS for Chinese men was better than for all Asian patients combined (P= .046). After controlling for D'Amico risk and in multivariate analysis, Chinese men still had improved OS than other Asian men after prostatectomy (P= .03). Conclusions: Asian-American men have differing prostate cancer characteristics. Future efforts to delineate and impact upon prostate cancer outcomes should categorize Asian men by subgroup in order to better elucidate biology, lifestyle factors and/or treatment preferences that may contribute to observed differences.

Original languageEnglish (US)
JournalClinical Genitourinary Cancer
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • D'Amico risk group
  • Ethnic subgroup
  • Gleason score
  • Radical prostatectomy
  • Recurrence-free survival

ASJC Scopus subject areas

  • Oncology
  • Urology

Fingerprint

Dive into the research topics of 'Prostate Cancer Characteristics and Outcomes after Prostatectomy in Asian-American Men'. Together they form a unique fingerprint.

Cite this