Prostate cancer susceptibility in men of African ancestry at 8q24

Ying Han, Kristin A. Rand, Dennis J. Hazelett, Sue A. Ingles, Rick A Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Fredrick R. Schumacher, Sonja I. Berndt, Zhaoming Wang, Jianfeng Xu, Nadin Rohland, David Reich, Arti Tandon, Bogdan Pasaniuc, Alex AllenDominique Quinque, Swapan Mallick, Dimple Notani, Michael G. Rosenfeld, Ranveer Singh Jayani, Suzanne Kolb, Susan M. Gapstur, Victoria L. Stevens, Curtis A. Pettaway, Edward D. Yeboah, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Anand P. Chokkalingam, Esther M. John, Adam B. Murphy, Lisa B. Signorello, John Carpten, M. Cristina Leske, Suh Yuh Wu, Anslem J.M. Hennis, Christine Neslund-Dudas, Ann W. Hsing, Lisa Chu, Phyllis J. Goodman, Eric A. Klein, S. Lilly Zheng, John S. Witte, Graham Casey, Alex Lubwama, Loreall C. Pooler, Xin Sheng, Gerhard A. Coetzee, Michael B. Cook, Stephen J. Chanock, Daniel O. Stram, Stephen Watya, William J. Blot, David V. Conti, Brian E. Henderson, Christopher A. Haiman

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The 8q24 region harbors multiple risk variants for distinct cancers, including 8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8 Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00 × 10-8, all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38 × 10-40; rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04 × 10-27; and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39 × 10-13). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.

Original languageEnglish (US)
Article numberdjv431
JournalJournal of the National Cancer Institute
Volume108
Issue number7
DOIs
StatePublished - 2016

Fingerprint

Prostatic Neoplasms
Gene Frequency
Long Noncoding RNA
Odds Ratio
Confidence Intervals
Ghana
Uganda
Prostate
Alleles
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Han, Y., Rand, K. A., Hazelett, D. J., Ingles, S. A., Kittles, R. A., Strom, S. S., ... Haiman, C. A. (2016). Prostate cancer susceptibility in men of African ancestry at 8q24. Journal of the National Cancer Institute, 108(7), [djv431]. https://doi.org/10.1093/jnci/djv431

Prostate cancer susceptibility in men of African ancestry at 8q24. / Han, Ying; Rand, Kristin A.; Hazelett, Dennis J.; Ingles, Sue A.; Kittles, Rick A; Strom, Sara S.; Rybicki, Benjamin A.; Nemesure, Barbara; Isaacs, William B.; Stanford, Janet L.; Zheng, Wei; Schumacher, Fredrick R.; Berndt, Sonja I.; Wang, Zhaoming; Xu, Jianfeng; Rohland, Nadin; Reich, David; Tandon, Arti; Pasaniuc, Bogdan; Allen, Alex; Quinque, Dominique; Mallick, Swapan; Notani, Dimple; Rosenfeld, Michael G.; Jayani, Ranveer Singh; Kolb, Suzanne; Gapstur, Susan M.; Stevens, Victoria L.; Pettaway, Curtis A.; Yeboah, Edward D.; Tettey, Yao; Biritwum, Richard B.; Adjei, Andrew A.; Tay, Evelyn; Truelove, Ann; Niwa, Shelley; Chokkalingam, Anand P.; John, Esther M.; Murphy, Adam B.; Signorello, Lisa B.; Carpten, John; Leske, M. Cristina; Wu, Suh Yuh; Hennis, Anslem J.M.; Neslund-Dudas, Christine; Hsing, Ann W.; Chu, Lisa; Goodman, Phyllis J.; Klein, Eric A.; Zheng, S. Lilly; Witte, John S.; Casey, Graham; Lubwama, Alex; Pooler, Loreall C.; Sheng, Xin; Coetzee, Gerhard A.; Cook, Michael B.; Chanock, Stephen J.; Stram, Daniel O.; Watya, Stephen; Blot, William J.; Conti, David V.; Henderson, Brian E.; Haiman, Christopher A.

In: Journal of the National Cancer Institute, Vol. 108, No. 7, djv431, 2016.

Research output: Contribution to journalArticle

Han, Y, Rand, KA, Hazelett, DJ, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA, Nemesure, B, Isaacs, WB, Stanford, JL, Zheng, W, Schumacher, FR, Berndt, SI, Wang, Z, Xu, J, Rohland, N, Reich, D, Tandon, A, Pasaniuc, B, Allen, A, Quinque, D, Mallick, S, Notani, D, Rosenfeld, MG, Jayani, RS, Kolb, S, Gapstur, SM, Stevens, VL, Pettaway, CA, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, John, EM, Murphy, AB, Signorello, LB, Carpten, J, Leske, MC, Wu, SY, Hennis, AJM, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Zheng, SL, Witte, JS, Casey, G, Lubwama, A, Pooler, LC, Sheng, X, Coetzee, GA, Cook, MB, Chanock, SJ, Stram, DO, Watya, S, Blot, WJ, Conti, DV, Henderson, BE & Haiman, CA 2016, 'Prostate cancer susceptibility in men of African ancestry at 8q24', Journal of the National Cancer Institute, vol. 108, no. 7, djv431. https://doi.org/10.1093/jnci/djv431
Han, Ying ; Rand, Kristin A. ; Hazelett, Dennis J. ; Ingles, Sue A. ; Kittles, Rick A ; Strom, Sara S. ; Rybicki, Benjamin A. ; Nemesure, Barbara ; Isaacs, William B. ; Stanford, Janet L. ; Zheng, Wei ; Schumacher, Fredrick R. ; Berndt, Sonja I. ; Wang, Zhaoming ; Xu, Jianfeng ; Rohland, Nadin ; Reich, David ; Tandon, Arti ; Pasaniuc, Bogdan ; Allen, Alex ; Quinque, Dominique ; Mallick, Swapan ; Notani, Dimple ; Rosenfeld, Michael G. ; Jayani, Ranveer Singh ; Kolb, Suzanne ; Gapstur, Susan M. ; Stevens, Victoria L. ; Pettaway, Curtis A. ; Yeboah, Edward D. ; Tettey, Yao ; Biritwum, Richard B. ; Adjei, Andrew A. ; Tay, Evelyn ; Truelove, Ann ; Niwa, Shelley ; Chokkalingam, Anand P. ; John, Esther M. ; Murphy, Adam B. ; Signorello, Lisa B. ; Carpten, John ; Leske, M. Cristina ; Wu, Suh Yuh ; Hennis, Anslem J.M. ; Neslund-Dudas, Christine ; Hsing, Ann W. ; Chu, Lisa ; Goodman, Phyllis J. ; Klein, Eric A. ; Zheng, S. Lilly ; Witte, John S. ; Casey, Graham ; Lubwama, Alex ; Pooler, Loreall C. ; Sheng, Xin ; Coetzee, Gerhard A. ; Cook, Michael B. ; Chanock, Stephen J. ; Stram, Daniel O. ; Watya, Stephen ; Blot, William J. ; Conti, David V. ; Henderson, Brian E. ; Haiman, Christopher A. / Prostate cancer susceptibility in men of African ancestry at 8q24. In: Journal of the National Cancer Institute. 2016 ; Vol. 108, No. 7.
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title = "Prostate cancer susceptibility in men of African ancestry at 8q24",
abstract = "The 8q24 region harbors multiple risk variants for distinct cancers, including 8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8 Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00 × 10-8, all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95{\%} confidence interval [CI] = 2.04 to 2.61, P = 2.38 × 10-40; rs72725879: RAF = 0.33, OR = 1.37, 95{\%} CI = 1.30 to 1.45, P = 3.04 × 10-27; and rs111906932: RAF = 0.03, OR = 1.79, 95{\%} CI = 1.53 to 2.08, P = 1.39 × 10-13). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.",
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T1 - Prostate cancer susceptibility in men of African ancestry at 8q24

AU - Han, Ying

AU - Rand, Kristin A.

AU - Hazelett, Dennis J.

AU - Ingles, Sue A.

AU - Kittles, Rick A

AU - Strom, Sara S.

AU - Rybicki, Benjamin A.

AU - Nemesure, Barbara

AU - Isaacs, William B.

AU - Stanford, Janet L.

AU - Zheng, Wei

AU - Schumacher, Fredrick R.

AU - Berndt, Sonja I.

AU - Wang, Zhaoming

AU - Xu, Jianfeng

AU - Rohland, Nadin

AU - Reich, David

AU - Tandon, Arti

AU - Pasaniuc, Bogdan

AU - Allen, Alex

AU - Quinque, Dominique

AU - Mallick, Swapan

AU - Notani, Dimple

AU - Rosenfeld, Michael G.

AU - Jayani, Ranveer Singh

AU - Kolb, Suzanne

AU - Gapstur, Susan M.

AU - Stevens, Victoria L.

AU - Pettaway, Curtis A.

AU - Yeboah, Edward D.

AU - Tettey, Yao

AU - Biritwum, Richard B.

AU - Adjei, Andrew A.

AU - Tay, Evelyn

AU - Truelove, Ann

AU - Niwa, Shelley

AU - Chokkalingam, Anand P.

AU - John, Esther M.

AU - Murphy, Adam B.

AU - Signorello, Lisa B.

AU - Carpten, John

AU - Leske, M. Cristina

AU - Wu, Suh Yuh

AU - Hennis, Anslem J.M.

AU - Neslund-Dudas, Christine

AU - Hsing, Ann W.

AU - Chu, Lisa

AU - Goodman, Phyllis J.

AU - Klein, Eric A.

AU - Zheng, S. Lilly

AU - Witte, John S.

AU - Casey, Graham

AU - Lubwama, Alex

AU - Pooler, Loreall C.

AU - Sheng, Xin

AU - Coetzee, Gerhard A.

AU - Cook, Michael B.

AU - Chanock, Stephen J.

AU - Stram, Daniel O.

AU - Watya, Stephen

AU - Blot, William J.

AU - Conti, David V.

AU - Henderson, Brian E.

AU - Haiman, Christopher A.

PY - 2016

Y1 - 2016

N2 - The 8q24 region harbors multiple risk variants for distinct cancers, including 8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8 Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00 × 10-8, all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38 × 10-40; rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04 × 10-27; and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39 × 10-13). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.

AB - The 8q24 region harbors multiple risk variants for distinct cancers, including 8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8 Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00 × 10-8, all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38 × 10-40; rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04 × 10-27; and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39 × 10-13). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.

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