Prostatic intraepithelial neoplasia: A lesion that may be confused with cancer on prostatic ultrasound

M. K. Brawer, M. A. Rennels, Raymond B Nagle, M. H. Soiderer, F. Lee

Research output: Contribution to journalArticle

16 Scopus citations


Most prostatic adenocarcinomas reveal a hypoechoic peripheral zone lesion on transrectal ultrasonography. Numerous benign processes can have similar transrectal ultrasound findings. We report 8 cases of transrectal ultrasound-guided prostatic biopsies of peripheral zone hypoechoic lesions that demonstrated prostatic intraepithelial neoplasia, a presumed premalignant lesion. Immunohistochemistry using an antibody directed against cytokeratins 5 and 14 was performed to exclude carcinoma. Of the men 2 had invasive carcinoma on repeat biopsy and 1 had carcinoma diagnosed on subsequent transurethral resection. Patients with prostatic intraepithelial neoplasia on biopsy of hypoechoic peripheral zone lesions merit careful monitoring.

Original languageEnglish (US)
Pages (from-to)1510-1512
Number of pages3
JournalJournal of Urology
Issue number6
Publication statusPublished - 1989


ASJC Scopus subject areas

  • Urology

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