Prostatic intraepithelial neoplasia: A lesion that may be confused with cancer on prostatic ultrasound

M. K. Brawer, M. A. Rennels, Raymond B Nagle, M. H. Soiderer, F. Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Most prostatic adenocarcinomas reveal a hypoechoic peripheral zone lesion on transrectal ultrasonography. Numerous benign processes can have similar transrectal ultrasound findings. We report 8 cases of transrectal ultrasound-guided prostatic biopsies of peripheral zone hypoechoic lesions that demonstrated prostatic intraepithelial neoplasia, a presumed premalignant lesion. Immunohistochemistry using an antibody directed against cytokeratins 5 and 14 was performed to exclude carcinoma. Of the men 2 had invasive carcinoma on repeat biopsy and 1 had carcinoma diagnosed on subsequent transurethral resection. Patients with prostatic intraepithelial neoplasia on biopsy of hypoechoic peripheral zone lesions merit careful monitoring.

Original languageEnglish (US)
Pages (from-to)1510-1512
Number of pages3
JournalJournal of Urology
Volume142
Issue number6
StatePublished - 1989

Fingerprint

Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Carcinoma
Biopsy
Keratin-14
Keratin-5
Ultrasonography
Adenocarcinoma
Immunohistochemistry
Antibodies

ASJC Scopus subject areas

  • Urology

Cite this

Prostatic intraepithelial neoplasia : A lesion that may be confused with cancer on prostatic ultrasound. / Brawer, M. K.; Rennels, M. A.; Nagle, Raymond B; Soiderer, M. H.; Lee, F.

In: Journal of Urology, Vol. 142, No. 6, 1989, p. 1510-1512.

Research output: Contribution to journalArticle

Brawer, MK, Rennels, MA, Nagle, RB, Soiderer, MH & Lee, F 1989, 'Prostatic intraepithelial neoplasia: A lesion that may be confused with cancer on prostatic ultrasound', Journal of Urology, vol. 142, no. 6, pp. 1510-1512.
Brawer, M. K. ; Rennels, M. A. ; Nagle, Raymond B ; Soiderer, M. H. ; Lee, F. / Prostatic intraepithelial neoplasia : A lesion that may be confused with cancer on prostatic ultrasound. In: Journal of Urology. 1989 ; Vol. 142, No. 6. pp. 1510-1512.
@article{f937930d313b4889a873694c499c7cde,
title = "Prostatic intraepithelial neoplasia: A lesion that may be confused with cancer on prostatic ultrasound",
abstract = "Most prostatic adenocarcinomas reveal a hypoechoic peripheral zone lesion on transrectal ultrasonography. Numerous benign processes can have similar transrectal ultrasound findings. We report 8 cases of transrectal ultrasound-guided prostatic biopsies of peripheral zone hypoechoic lesions that demonstrated prostatic intraepithelial neoplasia, a presumed premalignant lesion. Immunohistochemistry using an antibody directed against cytokeratins 5 and 14 was performed to exclude carcinoma. Of the men 2 had invasive carcinoma on repeat biopsy and 1 had carcinoma diagnosed on subsequent transurethral resection. Patients with prostatic intraepithelial neoplasia on biopsy of hypoechoic peripheral zone lesions merit careful monitoring.",
author = "Brawer, {M. K.} and Rennels, {M. A.} and Nagle, {Raymond B} and Soiderer, {M. H.} and F. Lee",
year = "1989",
language = "English (US)",
volume = "142",
pages = "1510--1512",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Prostatic intraepithelial neoplasia

T2 - A lesion that may be confused with cancer on prostatic ultrasound

AU - Brawer, M. K.

AU - Rennels, M. A.

AU - Nagle, Raymond B

AU - Soiderer, M. H.

AU - Lee, F.

PY - 1989

Y1 - 1989

N2 - Most prostatic adenocarcinomas reveal a hypoechoic peripheral zone lesion on transrectal ultrasonography. Numerous benign processes can have similar transrectal ultrasound findings. We report 8 cases of transrectal ultrasound-guided prostatic biopsies of peripheral zone hypoechoic lesions that demonstrated prostatic intraepithelial neoplasia, a presumed premalignant lesion. Immunohistochemistry using an antibody directed against cytokeratins 5 and 14 was performed to exclude carcinoma. Of the men 2 had invasive carcinoma on repeat biopsy and 1 had carcinoma diagnosed on subsequent transurethral resection. Patients with prostatic intraepithelial neoplasia on biopsy of hypoechoic peripheral zone lesions merit careful monitoring.

AB - Most prostatic adenocarcinomas reveal a hypoechoic peripheral zone lesion on transrectal ultrasonography. Numerous benign processes can have similar transrectal ultrasound findings. We report 8 cases of transrectal ultrasound-guided prostatic biopsies of peripheral zone hypoechoic lesions that demonstrated prostatic intraepithelial neoplasia, a presumed premalignant lesion. Immunohistochemistry using an antibody directed against cytokeratins 5 and 14 was performed to exclude carcinoma. Of the men 2 had invasive carcinoma on repeat biopsy and 1 had carcinoma diagnosed on subsequent transurethral resection. Patients with prostatic intraepithelial neoplasia on biopsy of hypoechoic peripheral zone lesions merit careful monitoring.

UR - http://www.scopus.com/inward/record.url?scp=0024817053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024817053&partnerID=8YFLogxK

M3 - Article

C2 - 2479777

AN - SCOPUS:0024817053

VL - 142

SP - 1510

EP - 1512

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -