Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA

Lisa Shubitz, Tao Peng, Robert Perrill, Julie Simons, Kris Orsborn, John N. Galgiani

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)3287-3289
Number of pages3
JournalInfection and Immunity
Volume70
Issue number6
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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