Protective role of wheat bran fiber: Data from marker trials

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effects of wheat bran fiber on surrogate endpoint biomarkers for colon cancer risk have been studied in rats and humans. In both species, there is little evidence that wheat bran fiber significantly modifies epithelial cell proliferation. In rat studies, however, dietary supplementation with wheat bran fiber has decreased mucosal formation of aberrant crypt foci, an important marker currently used to estimate the efficacy of colon cancer chemoprevention agents. In humans, wheat bran fiber has been shown to consistently decrease fecal bile acid concentrations, mainly by reducing toxic secondary bile acids.

Original languageEnglish (US)
Pages (from-to)32S-37S
JournalAmerican Journal of Medicine
Volume106
Issue number1 A
DOIs
StatePublished - Jan 25 1999

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Protective role of wheat bran fiber: Data from marker trials'. Together they form a unique fingerprint.

Cite this