Protein-based thermoplastic elastomers

Karthik Nagapudi, William T. Brinkman, Johannes Leisen, Benjamin S. Thomas, Elizabeth R. Wright, Carolyn Haller, Xiaoyi Wu, Robert P. Apkarian, Vincent P. Conticello, Elliot L. Chaikof

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Investigations of high molecular weight recombinant protein triblock copolymers demonstrate unique opportunities to systematically modify material microstructure on both nano- and meso-length scales in a manner not been previously demonstrated for protein polymer systems. Significantly, through the biosynthesis of BAB-type copolymers containing flanking, plastic-like end blocks and an elastomeric midblock, virtually cross-linked protein-based materials were generated that exhibit tunable properties in a manner completely analogous to synthetic thermoplastic elastomers. Through the rational choice of processing conditions that control meso- and nanoscale structure, changes of greater than 3 orders of magnitude in Young's modulus (0.03-35 MPa) and 5-fold in elongation to break (250-1300%) were observed. Extensibility of this range or magnitude has not been previously reported for virtually cross-linked copolymers that have been produced by either chemical or biosynthetic approaches. We anticipate that these versatile protein-based thermoplastic elastomers will find applications as novel scaffolds for tissue engineering and as new biomaterials for controlled drug release and cell encapsulation.

Original languageEnglish (US)
Pages (from-to)345-354
Number of pages10
JournalMacromolecules
Volume38
Issue number2
DOIs
StatePublished - Jan 25 2005
Externally publishedYes

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Thermoplastic elastomers
Proteins
Copolymers
Recombinant proteins
Biosynthesis
Biocompatible Materials
Scaffolds (biology)
Encapsulation
Tissue engineering
Recombinant Proteins
Biomaterials
Block copolymers
Elongation
Polymers
Elastic moduli
Molecular weight
Plastics
Microstructure
Processing
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Nagapudi, K., Brinkman, W. T., Leisen, J., Thomas, B. S., Wright, E. R., Haller, C., ... Chaikof, E. L. (2005). Protein-based thermoplastic elastomers. Macromolecules, 38(2), 345-354. https://doi.org/10.1021/ma0491199

Protein-based thermoplastic elastomers. / Nagapudi, Karthik; Brinkman, William T.; Leisen, Johannes; Thomas, Benjamin S.; Wright, Elizabeth R.; Haller, Carolyn; Wu, Xiaoyi; Apkarian, Robert P.; Conticello, Vincent P.; Chaikof, Elliot L.

In: Macromolecules, Vol. 38, No. 2, 25.01.2005, p. 345-354.

Research output: Contribution to journalArticle

Nagapudi, K, Brinkman, WT, Leisen, J, Thomas, BS, Wright, ER, Haller, C, Wu, X, Apkarian, RP, Conticello, VP & Chaikof, EL 2005, 'Protein-based thermoplastic elastomers', Macromolecules, vol. 38, no. 2, pp. 345-354. https://doi.org/10.1021/ma0491199
Nagapudi K, Brinkman WT, Leisen J, Thomas BS, Wright ER, Haller C et al. Protein-based thermoplastic elastomers. Macromolecules. 2005 Jan 25;38(2):345-354. https://doi.org/10.1021/ma0491199
Nagapudi, Karthik ; Brinkman, William T. ; Leisen, Johannes ; Thomas, Benjamin S. ; Wright, Elizabeth R. ; Haller, Carolyn ; Wu, Xiaoyi ; Apkarian, Robert P. ; Conticello, Vincent P. ; Chaikof, Elliot L. / Protein-based thermoplastic elastomers. In: Macromolecules. 2005 ; Vol. 38, No. 2. pp. 345-354.
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