Protein dynamics and the enzymatic reaction coordinate

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Abstract

This chapter discusses progress over the past 15 years in understanding the role of protein dynamics in enzymatically catalyzed chemical reactions. Research has shown that protein motion on all timescales from femtoseconds to milliseconds can contribute to function, and in particular in some enzymes there are sub-picosecond motions, on the same timescale as barrier passage, the couple directly to chemical transformation, and are thus part of the reaction coordinate. Approaches such as transition path sampling and committor analysis have greatly enhanced our understanding of these processes.

Original languageEnglish (US)
Title of host publicationDynamics in Enzyme Catalysis
EditorsJudith Klinman, Sharon Hammes-Schiffer
Pages189-208
Number of pages20
DOIs
StatePublished - Dec 1 2013

Publication series

NameTopics in Current Chemistry
Volume337
ISSN (Print)0340-1022

ASJC Scopus subject areas

  • Chemistry(all)

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    Schwartz, S. D. (2013). Protein dynamics and the enzymatic reaction coordinate. In J. Klinman, & S. Hammes-Schiffer (Eds.), Dynamics in Enzyme Catalysis (pp. 189-208). (Topics in Current Chemistry; Vol. 337). https://doi.org/10.1007/128_2012_412