Protein dynamics and the enzymatic reaction coordinate

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

This chapter discusses progress over the past 15 years in understanding the role of protein dynamics in enzymatically catalyzed chemical reactions. Research has shown that protein motion on all timescales from femtoseconds to milliseconds can contribute to function, and in particular in some enzymes there are sub-picosecond motions, on the same timescale as barrier passage, the couple directly to chemical transformation, and are thus part of the reaction coordinate. Approaches such as transition path sampling and committor analysis have greatly enhanced our understanding of these processes.

Original languageEnglish (US)
Title of host publicationTopics in Current Chemistry
Pages189-208
Number of pages20
Volume337
DOIs
StatePublished - 2013

Publication series

NameTopics in Current Chemistry
Volume337
ISSN (Print)03401022

Fingerprint

Chemical reactions
Proteins
Sampling
Enzymes
Research

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)

Cite this

Schwartz, S. D. (2013). Protein dynamics and the enzymatic reaction coordinate. In Topics in Current Chemistry (Vol. 337, pp. 189-208). (Topics in Current Chemistry; Vol. 337). https://doi.org/10.1007/128_2012_412

Protein dynamics and the enzymatic reaction coordinate. / Schwartz, Steven D.

Topics in Current Chemistry. Vol. 337 2013. p. 189-208 (Topics in Current Chemistry; Vol. 337).

Research output: Chapter in Book/Report/Conference proceedingChapter

Schwartz, SD 2013, Protein dynamics and the enzymatic reaction coordinate. in Topics in Current Chemistry. vol. 337, Topics in Current Chemistry, vol. 337, pp. 189-208. https://doi.org/10.1007/128_2012_412
Schwartz SD. Protein dynamics and the enzymatic reaction coordinate. In Topics in Current Chemistry. Vol. 337. 2013. p. 189-208. (Topics in Current Chemistry). https://doi.org/10.1007/128_2012_412
Schwartz, Steven D. / Protein dynamics and the enzymatic reaction coordinate. Topics in Current Chemistry. Vol. 337 2013. pp. 189-208 (Topics in Current Chemistry).
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