Protein promoting vibrations in enzyme catalysis - A conserved evolutionary motif

Joshua S. Mincer, Steven D. Schwartz

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A computational method to identify residues important in creating a protein promoting vibration (PPV) in enzymes was previously developed and applied to horse liver alcohol dehydrogenase (HLADH), resulting in the identification of eight important residues. From these residues, we define a sequence motif, the PPV generating sequence, and find it to be unique and general to a larger group of alcohol dehydrogenases from diverse sources, demonstrating that nature has selected for the PPV generating sequence.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalJournal of Proteome Research
Volume2
Issue number4
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

Keywords

  • Alcohol dehydrogenase
  • Computational algorithms
  • Enzyme catalysis
  • Molecular dynamics
  • Multiple alignment
  • Promoting vibration
  • Protein design
  • Protein dynamics
  • Quantum tunneling
  • Sequence homology

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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