Protein-targeting determinants in the secretory pathway of apicomplexan parasites

Achim J. Kaasch, Keith A. Joiner

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Apicomplexan parasites possess a highly specialized secretory apparatus. The timed secretion of proteins from three different organelles - micronemes, rhoptries and dense granules - serves to establish and maintain a parasitophorous vacuole inside the host cell in which the parasites can divide. Recent efforts have identified components that sort apicomplexan proteins to these unusual secretory organelles and have shown that this machinery is evolutionarily conserved across species. Concise amino acid sequences (e.g. tyrosine-based motifs) within the targeted protein determine their destination in Apicomplexa in a way similar to mammalian cells. Additionally, the parasite exploits new or unusual mechanisms of protein targeting (e.g. post-secretory membrane insertion).

Original languageEnglish (US)
Pages (from-to)422-428
Number of pages7
JournalCurrent Opinion in Microbiology
Volume3
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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