Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities

Kelli C. Kiekens, Olivia Talarico, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A multimodality endoscope system has been designed for early detection of ovarian cancer. Multiple illumination and detection systems must be integrated in a compact, stable, transportable configuration to meet the requirements of a clinical setting. The proximal configuration presented here supports visible light navigation with a large field of view and low resolution, high resolution multiphoton microscopy (MPM), and high resolution optical coherence microscopy (OCM). All modalities are integrated into a single optical system in the endoscope. The system requires two light sources: a green laser for visible light navigation and a compact fiber based femtosecond laser for MPM and OCM. Using an inline wavelength division multiplexer, the two sources are combined into a single mode fiber. To accomplish OCM, a fiber coupler is used to separate the femtosecond laser into a reference arm and signal arm. The reflected reference arm and the signal from the sample are interfered and wavelength separated by a reflection grating and detected using a linear array. The MPM signal is collimated and goes through a series of filters to separate the 2nd and 3rd harmonics as well as twophoton excitation florescence (2PEF) and 3PEF. Each signal is independently detected on a photo multiplier tube and amplified. The visible light is collected by multiple high numerical aperture fibers at the endoscope tip which are bundled into one SMA adapter at the proximal end and connected to a photodetector. This integrated system design is compact, efficient and meets both optical and mechanical requirements for clinical applications.

Original languageEnglish (US)
Title of host publicationOptical Diagnostics and Sensing XVIII
Subtitle of host publicationToward Point-of-Care Diagnostics
PublisherSPIE
Volume10501
ISBN (Electronic)9781510614871
DOIs
StatePublished - Jan 1 2018
Externally publishedYes
EventOptical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics 2018 - San Francisco, United States
Duration: Jan 29 2018Jan 30 2018

Other

OtherOptical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics 2018
CountryUnited States
CitySan Francisco
Period1/29/181/30/18

Fingerprint

endoscopes
Endoscopy
Endoscopes
Microscopy
Microscopic examination
microscopy
Light
fibers
Ultrashort pulses
navigation
Lasers
Fibers
Navigation
Optical Devices
lasers
adapters
Wavelength
spectral mixture analysis
requirements
Lighting

Keywords

  • Multimodality endoscope
  • Multiphoton Microscopy
  • Optical Coherence Microscopy
  • Ovarian cancer detection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Kiekens, K. C., Talarico, O., & Barton, J. K. (2018). Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities. In Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics (Vol. 10501). [1050119] SPIE. https://doi.org/10.1117/12.2286971

Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities. / Kiekens, Kelli C.; Talarico, Olivia; Barton, Jennifer K.

Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics. Vol. 10501 SPIE, 2018. 1050119.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kiekens, KC, Talarico, O & Barton, JK 2018, Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities. in Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics. vol. 10501, 1050119, SPIE, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics 2018, San Francisco, United States, 1/29/18. https://doi.org/10.1117/12.2286971
Kiekens KC, Talarico O, Barton JK. Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities. In Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics. Vol. 10501. SPIE. 2018. 1050119 https://doi.org/10.1117/12.2286971
Kiekens, Kelli C. ; Talarico, Olivia ; Barton, Jennifer K. / Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities. Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics. Vol. 10501 SPIE, 2018.
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