Pseudovasculitis: mechanisms of vascular injury and clinical spectrum.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Pseudovasculitis, vasculitis-like syndromes, or mimics of vasculitis represent a heterogeneous collection of disorders that are capable of simulating a vasculitic disorder. Some conditions such as cardiac myxomas, cholesterol embolization, and fibromuscular dysplasia are more apt to cause confusion, but numerous other conditions can do so also. Inappropriate diagnosis leads to delay or absence of proper management and exposure to potentially deleterious treatment modalities such as corticosteroids and cytotoxic agents. The diagnosis of a pseudovasculitic disorder requires a high index of suspicion and should always be part of the differential diagnosis of vasculitis. The endothelium is thought to be pivotal in vascular injury; much has been learned using in vitro human umbilical vein endothelial cell cultures. Application of this knowledge to human disease and to vasculitic disorders and their imitators is still premature.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalCurrent Rheumatology Reports
Volume4
Issue number1
StatePublished - Feb 2002
Externally publishedYes

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Vascular System Injuries
Vasculitis
Fibromuscular Dysplasia
Myxoma
Human Umbilical Vein Endothelial Cells
Cytotoxins
Endothelium
Adrenal Cortex Hormones
Differential Diagnosis
Cell Culture Techniques
Cholesterol
Therapeutics

ASJC Scopus subject areas

  • Rheumatology

Cite this

Pseudovasculitis : mechanisms of vascular injury and clinical spectrum. / Grau, Rafael G.

In: Current Rheumatology Reports, Vol. 4, No. 1, 02.2002, p. 83-89.

Research output: Contribution to journalArticle

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