[PSI+]: An epigenetic modulator of translation termination efficiency

Tricia R Serio, S. L. Lindquist

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The [PSI+] factor of the yeast Saccharomyces cerevisiae is an epigenetic regulator of translation termination. More than three decades ago, genetic analysis of the transmission of [PSI+] revealed a complex and often contradictory series of observations. However, many of these discrepancies may now be reconciled by a revolutionary hypothesis: protein conformation-based inheritance (the prion hypothesis). This model predicts that a single protein can stably exist in at least two distinct physical states, each associated with a different phenotype. Propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other. Mounting genetic and biochemical evidence suggests that the determinant of [PSI+] is the nuclear encoded Sup35p, a component of the translation termination complex. Here we review the series of experiments supporting the yeast prion hypothesis and provide another look at the 30 years of work preceding this theory in light of our current state of knowledge.

Original languageEnglish (US)
Pages (from-to)661-703
Number of pages43
JournalAnnual Review of Cell and Developmental Biology
Volume15
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Prions
Epigenomics
Yeasts
Protein Conformation
Saccharomyces cerevisiae
Molecular Biology
Proteins
Phenotype

Keywords

  • Amyloid
  • Epigenetic
  • Nonsense suppression
  • Prion
  • Sup35

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

[PSI+] : An epigenetic modulator of translation termination efficiency. / Serio, Tricia R; Lindquist, S. L.

In: Annual Review of Cell and Developmental Biology, Vol. 15, 1999, p. 661-703.

Research output: Contribution to journalArticle

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