Psychological stress and immunological modulations in early-stage melanoma patients

Erika Richtig, Eva Maria Trapp, Alexander Avian, Hans Peter Brezinsek, Michael Trapp, Josef Wilhelm Egger, Hans Peter Kapfhammer, Peter Michael Rohrer, Andrea Berghold, Clara Curiellewandrowski, Ulrike Demel

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7 Scopus citations

Abstract

Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at baseline and post-stress test time-points. Following the stress test lower levels of interleukin (IL)-6 were observed in the melanoma group compared with healthy volunteers (p = 0.044). IL-10 increased significantly in the control group 30 min after the stress test (p = 0.002) in comparison with the melanoma group (p = 0.407). CCL5/Rantes decreased significantly in the melanoma group, whereas CD16/CD56+ natural killer cells increased in both groups, with a sharp decrease below baseline after stress in the melanoma group (p = 0.001). This pilot study shows an altered immunological response to stressors in melanoma patients.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalActa Dermato-Venereologica
Volume95
Issue number6
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Chemokines
  • Cytokines
  • Lymphocytes
  • Melanoma
  • Stress

ASJC Scopus subject areas

  • Dermatology

Cite this

Richtig, E., Trapp, E. M., Avian, A., Brezinsek, H. P., Trapp, M., Egger, J. W., Kapfhammer, H. P., Rohrer, P. M., Berghold, A., Curiellewandrowski, C., & Demel, U. (2015). Psychological stress and immunological modulations in early-stage melanoma patients. Acta Dermato-Venereologica, 95(6), 691-695. https://doi.org/10.2340/00015555-2045