TY - JOUR
T1 - Psychological stress and immunological modulations in early-stage melanoma patients
AU - Richtig, Erika
AU - Trapp, Eva Maria
AU - Avian, Alexander
AU - Brezinsek, Hans Peter
AU - Trapp, Michael
AU - Egger, Josef Wilhelm
AU - Kapfhammer, Hans Peter
AU - Rohrer, Peter Michael
AU - Berghold, Andrea
AU - Curiellewandrowski, Clara
AU - Demel, Ulrike
N1 - Publisher Copyright:
© 2015 The Authors.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at baseline and post-stress test time-points. Following the stress test lower levels of interleukin (IL)-6 were observed in the melanoma group compared with healthy volunteers (p = 0.044). IL-10 increased significantly in the control group 30 min after the stress test (p = 0.002) in comparison with the melanoma group (p = 0.407). CCL5/Rantes decreased significantly in the melanoma group, whereas CD16/CD56+ natural killer cells increased in both groups, with a sharp decrease below baseline after stress in the melanoma group (p = 0.001). This pilot study shows an altered immunological response to stressors in melanoma patients.
AB - Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at baseline and post-stress test time-points. Following the stress test lower levels of interleukin (IL)-6 were observed in the melanoma group compared with healthy volunteers (p = 0.044). IL-10 increased significantly in the control group 30 min after the stress test (p = 0.002) in comparison with the melanoma group (p = 0.407). CCL5/Rantes decreased significantly in the melanoma group, whereas CD16/CD56+ natural killer cells increased in both groups, with a sharp decrease below baseline after stress in the melanoma group (p = 0.001). This pilot study shows an altered immunological response to stressors in melanoma patients.
KW - Chemokines
KW - Cytokines
KW - Lymphocytes
KW - Melanoma
KW - Stress
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U2 - 10.2340/00015555-2045
DO - 10.2340/00015555-2045
M3 - Article
C2 - 25587794
AN - SCOPUS:84932114216
VL - 95
SP - 691
EP - 695
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 6
ER -