Pulmonary and nasal anti-inflammatory and anti-allergy inhalation aerosol delivery systems

Xiao Wu, Oreoluwa O. Adedoyin, Heidi - Mansour

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Most respiratory infections, diseases and allergic reactions have varying degrees of inflammation. Inflammation is a natural immunodefensive response to the presence of allergens or foreign particles that come into contact or affect the cells and tissues within the respiratory tract. The three main types of therapeutic drug classes available for anti-inflammatory and anti-allergy effects are corticosteroids, antihistamines and decongestants. Corticosteroid drugs for pulmonary inhalation and/or nasal delivery include beclomethasone dipropionate, budesonide, ciclesonide, fluticasone furoate, fluticasone propionate, mometasone furoate, and triamcinolone acetonide. Antihistamine drugs for nasal delivery include azelastine and olopatadine. Two common decongestants available are oxymetazoline and phenylephrine. Another therapeutic class, the anticholinergic agents, such as ipratropium bromide and tiotropium bromide, are used in pulmonary delivery in the treatment of inflammatory diseases such as asthma and chronic obstructive pulmonary disease. The mast cell stabilizer therapeutic class, cromolyn sodium, can be used to prevent and relieve nasal allergic symptoms. Additionally cromolyn sodium was the first dry powder inhaler product for pulmonary drug delivery several decades ago and currently is on the market as a pressurized metered dose inhaler for pulmonary inhalation delivery. Based on the devices used in pulmonary drug delivery, this route can be subdivided into three categories; namely nebulizers, pressurized metered dose inhalers, and dry powder inhalers. Nasal delivery of anti-inflammatory and antiallergy drugs is most commonly available commercially in an aqueous spray form. This article comprehensively reviews and discusses different kinds of drugs used for anti-inflammatory and anti-allergic effects via the pulmonary and nasal delivery route, as well as their mechanisms of action, marketed products, disease state indications while highlighting drug delivery and therapeutic aspects.

Original languageEnglish (US)
Pages (from-to)215-229
Number of pages15
JournalAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Volume10
Issue number3
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Aerosols
Nose
Inhalation
Hypersensitivity
Anti-Inflammatory Agents
Lung
Pharmaceutical Preparations
Dry Powder Inhalers
Nasal Decongestants
Metered Dose Inhalers
Cromolyn Sodium
Mometasone Furoate
Histamine Antagonists
azelastine
Adrenal Cortex Hormones
Oxymetazoline
Inhalation Administration
Ipratropium
Inflammation
Therapeutics

Keywords

  • Aerosol
  • Anti-allergy
  • Anti-cholinergics
  • Anti-inflammatory
  • Antihistamines
  • Beta agonists
  • Corticosteroids
  • Decongestants
  • Long-acting
  • Mast cell stabilizers
  • Nasal spray
  • Pulmonary drug delivery
  • Rhinitis
  • Short-acting

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Pulmonary and nasal anti-inflammatory and anti-allergy inhalation aerosol delivery systems. / Wu, Xiao; Adedoyin, Oreoluwa O.; Mansour, Heidi -.

In: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, Vol. 10, No. 3, 06.2011, p. 215-229.

Research output: Contribution to journalArticle

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AB - Most respiratory infections, diseases and allergic reactions have varying degrees of inflammation. Inflammation is a natural immunodefensive response to the presence of allergens or foreign particles that come into contact or affect the cells and tissues within the respiratory tract. The three main types of therapeutic drug classes available for anti-inflammatory and anti-allergy effects are corticosteroids, antihistamines and decongestants. Corticosteroid drugs for pulmonary inhalation and/or nasal delivery include beclomethasone dipropionate, budesonide, ciclesonide, fluticasone furoate, fluticasone propionate, mometasone furoate, and triamcinolone acetonide. Antihistamine drugs for nasal delivery include azelastine and olopatadine. Two common decongestants available are oxymetazoline and phenylephrine. Another therapeutic class, the anticholinergic agents, such as ipratropium bromide and tiotropium bromide, are used in pulmonary delivery in the treatment of inflammatory diseases such as asthma and chronic obstructive pulmonary disease. The mast cell stabilizer therapeutic class, cromolyn sodium, can be used to prevent and relieve nasal allergic symptoms. Additionally cromolyn sodium was the first dry powder inhaler product for pulmonary drug delivery several decades ago and currently is on the market as a pressurized metered dose inhaler for pulmonary inhalation delivery. Based on the devices used in pulmonary drug delivery, this route can be subdivided into three categories; namely nebulizers, pressurized metered dose inhalers, and dry powder inhalers. Nasal delivery of anti-inflammatory and antiallergy drugs is most commonly available commercially in an aqueous spray form. This article comprehensively reviews and discusses different kinds of drugs used for anti-inflammatory and anti-allergic effects via the pulmonary and nasal delivery route, as well as their mechanisms of action, marketed products, disease state indications while highlighting drug delivery and therapeutic aspects.

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KW - Mast cell stabilizers

KW - Nasal spray

KW - Pulmonary drug delivery

KW - Rhinitis

KW - Short-acting

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