Pulmonary function after non-heart-beating lung donation in a survival model

Scott A. Buchanan, Nuno F. DeLima, Oliver A.R. Binns, Michael C. Mauney, Jeffrey T. Cope, Scott E. Langenburg, Kim S. Shockey, Joe D. Bianchi, Vikas I. Parekh, Curtis G. Tribble, Irving L. Kron

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background.: Lung procurement from recently deceased cadavers has been suggested to enlarge the limited donor pool. We hypothesized that lungs harvested from non-heart-beating donors (NHBD) would function as well as those harvested from heart-beating donors. Methods.: Sixteen adult swine underwent left lung allotransplantation. Controls received lungs procured from heart-beating donors, NHBD pigs received lungs immediately harvested from donors after death from asphyxiation, and NHBD-15 and NHBD-30 pigs received lungs harvested after 15 and 30 minutes after asphyxiation. Results.: After 1 week of survival, mean dynamic airway compliance (mL/cm H2O ± standard error of the mean) was 16.3 ± 0.7 in controls, and 17.3 ± 1.0, 16.4 ± 6.0, and 7.3 ± 1.6 in the NHBD, NHBD-15, and NHBD-30 groups, respectively (p = 0.02, NHBD-30 versus others combined). No significant differences were noted in the pulmonary venous partial pressure of oxygen or pulmonary vascular hemodynamics compared with controls. Conclusions.: The decrease in airway compliance noted in the NHBD-30 group may reflect an exacerbation of reperfusion injury caused by 30 minutes of warm ischemia during organ retrieval. We conclude that posttransplantation lung function using an NHBD with up to 15 minutes of warm ischemia is equivalent to lung function after heart-beating harvest.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalThe Annals of Thoracic Surgery
Volume60
Issue number1
DOIs
StatePublished - Jul 1995
Externally publishedYes

Fingerprint

Lung
Warm Ischemia
Swine
Asphyxia
Compliance
Tissue and Organ Harvesting
Venous Pressure
Partial Pressure
Reperfusion Injury
Cadaver
Blood Vessels
Hemodynamics
Oxygen

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Buchanan, S. A., DeLima, N. F., Binns, O. A. R., Mauney, M. C., Cope, J. T., Langenburg, S. E., ... Kron, I. L. (1995). Pulmonary function after non-heart-beating lung donation in a survival model. The Annals of Thoracic Surgery, 60(1), 38-46. https://doi.org/10.1016/S0003-4975(95)00322-3

Pulmonary function after non-heart-beating lung donation in a survival model. / Buchanan, Scott A.; DeLima, Nuno F.; Binns, Oliver A.R.; Mauney, Michael C.; Cope, Jeffrey T.; Langenburg, Scott E.; Shockey, Kim S.; Bianchi, Joe D.; Parekh, Vikas I.; Tribble, Curtis G.; Kron, Irving L.

In: The Annals of Thoracic Surgery, Vol. 60, No. 1, 07.1995, p. 38-46.

Research output: Contribution to journalArticle

Buchanan, SA, DeLima, NF, Binns, OAR, Mauney, MC, Cope, JT, Langenburg, SE, Shockey, KS, Bianchi, JD, Parekh, VI, Tribble, CG & Kron, IL 1995, 'Pulmonary function after non-heart-beating lung donation in a survival model', The Annals of Thoracic Surgery, vol. 60, no. 1, pp. 38-46. https://doi.org/10.1016/S0003-4975(95)00322-3
Buchanan SA, DeLima NF, Binns OAR, Mauney MC, Cope JT, Langenburg SE et al. Pulmonary function after non-heart-beating lung donation in a survival model. The Annals of Thoracic Surgery. 1995 Jul;60(1):38-46. https://doi.org/10.1016/S0003-4975(95)00322-3
Buchanan, Scott A. ; DeLima, Nuno F. ; Binns, Oliver A.R. ; Mauney, Michael C. ; Cope, Jeffrey T. ; Langenburg, Scott E. ; Shockey, Kim S. ; Bianchi, Joe D. ; Parekh, Vikas I. ; Tribble, Curtis G. ; Kron, Irving L. / Pulmonary function after non-heart-beating lung donation in a survival model. In: The Annals of Thoracic Surgery. 1995 ; Vol. 60, No. 1. pp. 38-46.
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abstract = "Background.: Lung procurement from recently deceased cadavers has been suggested to enlarge the limited donor pool. We hypothesized that lungs harvested from non-heart-beating donors (NHBD) would function as well as those harvested from heart-beating donors. Methods.: Sixteen adult swine underwent left lung allotransplantation. Controls received lungs procured from heart-beating donors, NHBD pigs received lungs immediately harvested from donors after death from asphyxiation, and NHBD-15 and NHBD-30 pigs received lungs harvested after 15 and 30 minutes after asphyxiation. Results.: After 1 week of survival, mean dynamic airway compliance (mL/cm H2O ± standard error of the mean) was 16.3 ± 0.7 in controls, and 17.3 ± 1.0, 16.4 ± 6.0, and 7.3 ± 1.6 in the NHBD, NHBD-15, and NHBD-30 groups, respectively (p = 0.02, NHBD-30 versus others combined). No significant differences were noted in the pulmonary venous partial pressure of oxygen or pulmonary vascular hemodynamics compared with controls. Conclusions.: The decrease in airway compliance noted in the NHBD-30 group may reflect an exacerbation of reperfusion injury caused by 30 minutes of warm ischemia during organ retrieval. We conclude that posttransplantation lung function using an NHBD with up to 15 minutes of warm ischemia is equivalent to lung function after heart-beating harvest.",
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AU - Cope, Jeffrey T.

AU - Langenburg, Scott E.

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