Pulmonary macrophages are involved in reperfusion injury after lung transplantation

Steven M. Fiser, Curtis G. Tribble, Stewart M. Long, Aditya K. Kaza, John A. Kern, Irving L. Kron

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Background. Reperfusion injury is a perplexing cause of early graft failure after lung transplantation. Although recipient neutrophils are thought to have a role in the development of reperfusion injury, some researchers have shown that neutrophils are not involved in its earliest phase. Intrinsic donor pulmonary macrophages may be responsible for this early phase of injury. Using the macrophage inhibitor gadolinium chloride, we attempted to investigate the role of pulmonary macrophages in reperfusion injury after lung transplantation. Methods. Using our isolated, ventilated, bloodperfused rabbit lung model, all groups underwent lung harvest followed by 18-hour storage (4°C) and blood reperfusion for 30 minutes. Group I served as a control. Group II received gadolinium chloride at 7 mg/kg 24 hours before harvest. Group III received gadolinium chloride at 14 mg/kg 24 hours before harvest. Results. Group III had significantly improved arterial oxygenation and pulmonary artery pressures compared with groups I and II after 30 minutes of reperfusion. Conclusions. The earliest phase of reperfusion injury after lung transplantation involves donor pulmonary macrophages.

Original languageEnglish (US)
Pages (from-to)1134-1139
Number of pages6
JournalAnnals of Thoracic Surgery
Volume71
Issue number4
DOIs
StatePublished - May 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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