Pulmonary vascular barrier regulation by thrombin and edg receptors

Jeffrey R. Jacobson, Joe G.N. Garcia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lung vascular permeability is directly determined by the integrity of the endothelial cell (EC) monolayer, which involves dynamic regulation by the actomyosin cytoskeleton with subsequent effects on cell - cell and cell - matrix interactions. Although the list of biochemical and biophysical agonists that alter EC barrier regulation is extensive, in this chapter we consider two in particular - the barrier-disruptive serine protease thrombin and barrier-enhancing sphingosine-1-phosphate, an activator of the Edg receptor. Both agonists, via elaborate receptor-specific and tightly orchestrated signaling pathways, offer important insights into lung vascular barrier regulation with respect to the role of individual cellular components and signaling events that target the endothelial cytoskeleton. Additionally, we detail the combined effect of thrombin and cyclic stretch, mechanistically distinct agonists, to provide further insight into lung vascular regulation. Our understanding of EC barrier regulation and lung vascular permeability has advanced remarkably in only a short time and, with the use of newly available technologies, will undoubtedly continue to rapidly evolve.

Original languageEnglish (US)
Title of host publicationCell Signaling in Vascular Inflammation
PublisherHumana Press
Pages137-145
Number of pages9
ISBN (Print)1588295257, 9781588295255
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • PAR1
  • Thrombin
  • actin
  • cytoskeleton
  • endothelial
  • mechanical stretch
  • permeability
  • sphingosine-1-phosphate
  • transendothelial electrical resistance
  • vascular leak

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Jacobson, J. R., & Garcia, J. G. N. (2005). Pulmonary vascular barrier regulation by thrombin and edg receptors. In Cell Signaling in Vascular Inflammation (pp. 137-145). Humana Press. https://doi.org/10.1007/978-1-59259-909-7_14