Pulmonary vascular dysfunction in metabolic syndrome

Conor Willson, Makiko Watanabe, Atsumi Tsuji-Hosokawa, Ayako Makino

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Metabolic syndrome is a critically important precursor to the onset of many diseases, such as cardiovascular disease, and cardiovascular disease is the leading cause of death worldwide. The primary risk factors of metabolic syndrome include hyperglycaemia, abdominal obesity, dyslipidaemia, and high blood pressure. It has been well documented that metabolic syndrome alters vascular endothelial and smooth muscle cell functions in the heart, brain, kidney and peripheral vessels. However, there is less information available regarding how metabolic syndrome can affect pulmonary vascular function and ultimately increase an individual's risk of developing various pulmonary vascular diseases, such as pulmonary hypertension. Here, we review in detail how metabolic syndrome affects pulmonary vascular function. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)1121-1141
Number of pages21
JournalJournal of Physiology
Issue number4
StatePublished - Feb 15 2019


  • Diabetes
  • Insulin resistance
  • dyslipidemia
  • obesity
  • pulmonary artery
  • pulmonary hypertension

ASJC Scopus subject areas

  • Physiology


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