Pulvinulin a, graminin c, and cis-gregatin b - new natural furanones from pulvinula sp. 11120, a Fungal endophyte of cupressus arizonica

E. M. Kithsiri Wijeratne, Yaming Xu, Anne E Arnold, Leslie Gunatilaka

Research output: Contribution to journalArticle

5 Scopus citations


Three new natural furanones, pulvinulin A (1), graminin C (2), and cis-gregatin B (3), together with the known fungal metabolites, graminin B (4) and 10-norparvulenone (5), were isolated from Pulvinula sp. 11120, an endophytic fungal strain occurring in healthy foliage of Cupressus arizonica (Arizona cypress). The structures of 1 and 2 were elucidated by the analysis of their spectroscopic data and chemical interconversions, and that of 3 was determined by comparison with data for synthetic cis-gregatin B. Comparison of spectroscopic data of 4 and 5 with those reported identified them as graminin B and 10-norparvulenone, respectively. Metabolites 1-4 exhibited antibacterial activity against E. Coli.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalNatural Product Communications
Issue number1
Publication statusPublished - 2015



  • Cis-Gregatin B.
  • Cupressus arizonica
  • Endophyte
  • Furanones
  • Graminin C
  • Pulvinula sp. 11120
  • Pulvinulin A

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science
  • Medicine(all)

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