Three new natural furanones, pulvinulin A (1), graminin C (2), and cis-gregatin B (3), together with the known fungal metabolites, graminin B (4) and 10-norparvulenone (5), were isolated from Pulvinula sp. 11120, an endophytic fungal strain occurring in healthy foliage of Cupressus arizonica (Arizona cypress). The structures of 1 and 2 were elucidated by the analysis of their spectroscopic data and chemical interconversions, and that of 3 was determined by comparison with data for synthetic cis-gregatin B. Comparison of spectroscopic data of 4 and 5 with those reported identified them as graminin B and 10-norparvulenone, respectively. Metabolites 1-4 exhibited antibacterial activity against E. Coli.
|Original language||English (US)|
|Number of pages||5|
|Journal||Natural Product Communications|
|Publication status||Published - 2015|
- Cis-Gregatin B.
- Cupressus arizonica
- Graminin C
- Pulvinula sp. 11120
- Pulvinulin A
ASJC Scopus subject areas
- Drug Discovery
- Complementary and alternative medicine
- Plant Science