Purine metabolism in pigs and humans and its implications for xenotransplantation

R. T. Smolenski, Z. Khalpey, A. Yuen, H. Dziewit, E. M. Slominska, T. Borkowski, M. Zdunek, Z. Kochan, J. Karbowska, M. Lavitrano, M. H. Yacoub

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We compared concentrations of nucleotide substrates and activities of enzymes of nucleotide metabolism in pig and human blood, heart, and kidney. The most important difference was lower ecto-5′-nucleotidase (E5′N) activity in both pig hearts and kidney. Furthermore, higher hypoxanthine, inosine, adenine, and uracil, but lower undine and uric acid concentrations were observed in pig blood as compared to human. A twofold increase in UTP concentration has been observed in pig hearts following 4 h perfusion with human blood. Purine metabolism is an important target for genetic and pharmacological manipulation during xenotransplantations.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume24
Issue number4
DOIs
StatePublished - Jul 22 2005

Keywords

  • ATP
  • Ecto-5′-Nucleotidase
  • Nucleotides
  • Purine Metabolites
  • UTP
  • Xenotransplantation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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