Pyrrolo[1, 4]benzodiazepine Antibiotics. Biosynthesis of the Antitumor Antibiotic Sibiromycin by Streptosporangium sibiricum

Laurence H. Hurley, William L. Lasswell, Ravinder K. Malhotra, Nobel V. Das

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum requires the construction of four units: the amino sugar from glucose; the anthranilate ring from dl-tryptophan probably via kynurenine; the aromatic methyl group from methionine; the propylidene proline from l-tyrosine with the loss of two aromatic carbons and addition of a C-l from methionine. Retention of tritium from dl-[5-3H]tryptophan in sibiromycin suggests an NIH shift during hydroxylation of an intermediate.

Original languageEnglish (US)
Pages (from-to)4225-4229
Number of pages5
JournalBiochemistry
Volume18
Issue number19
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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