QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Frances A. Tylavsky, Timothy Lohman, Barbara A. Blunt, Dale A. Schoeller, Thomas Fuerst, Jane A. Cauley, Michael C. Nevitt, Marjolein Visser, Tamara B. Harris

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52 Scopus citations

Abstract

This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

Original languageEnglish (US)
Pages (from-to)959-965
Number of pages7
JournalJournal of Applied Physiology
Volume94
Issue number3
DOIs
StatePublished - Mar 1 2003

Keywords

  • Body composition
  • Dual-energy X-ray absorptiometer
  • Four-component model of body composition
  • Hydration of fat-free mass
  • Total body water

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Tylavsky, F. A., Lohman, T., Blunt, B. A., Schoeller, D. A., Fuerst, T., Cauley, J. A., Nevitt, M. C., Visser, M., & Harris, T. B. (2003). QDR 4500A DXA overestimates fat-free mass compared with criterion methods. Journal of Applied Physiology, 94(3), 959-965. https://doi.org/10.1152/japplphysiol.00732.2002