Quantitation of infarct size in patients with chronic coronary artery disease using rest-redistribution Tl-201 myocardial perfusion SPECT: Correlation with contrast-enhanced cardiac magnetic resonance

David S. Fieno, Louise E J Thomson, Piotr Slomka, Aiden Abidov, John D. Friedman, Guido Germano, Daniel S. Berman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Rest and rest-redistribution thallium 201 myocardial perfusion single photon emission computed tomography (SPECT) (MPS) has been incompletely validated in patients for determination of the total amount of scarred myocardium. We sought to determine whether rest or redistribution Tl-201 MPS provides an accurate determination of infarct size as defined by delayed contrast-enhanced cardiac magnetic resonance (CMR). Methods and Results: We studied patients (n = 44) with chronic coronary artery disease referred for rest-redistribution Tl-201 MPS, who were also studied by contrast-enhanced CMR within 3 ± 4 days. Patients were considered retrospectively based on a series of patients referred for clinically indicated MPS. Defect size, as a percent of left ventricular mass (% LV), was determined by quantitative perfusion SPECT (QPS) and compared with the volume of delayed hyperenhancement on contrast-enhanced CMR, normalized to LV mass. Infarct size varied from 0% to 43% LV. Rest QPS defect size correlated with the amount of nonviable myocardium assessed by contrast-enhanced CMR (r = 0.76; mean difference, 4.3% ± 8.0% LV). When delayed thallium data were considered, redistribution QPS was superior to rest QPS for determination of infarct size (redistribution r = 0.90; mean difference, 2.4% ± 5.2% LV; P = .03 vs rest). Conclusion: Rest-redistribution Tl-201 MPS provides a more accurate measurement of total infarct size than rest-only Tl-201 MPS and correlates with contrast-enhanced CMR.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalJournal of Nuclear Cardiology
Volume14
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Single-Photon Emission-Computed Tomography
Coronary Artery Disease
Magnetic Resonance Spectroscopy
Perfusion
Thallium
Myocardium

Keywords

  • Contrast-enhanced cardiac magnetic resonance
  • myocardial infarction
  • rest-redistribution
  • single photon emission computed tomography
  • thallium 201

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Quantitation of infarct size in patients with chronic coronary artery disease using rest-redistribution Tl-201 myocardial perfusion SPECT : Correlation with contrast-enhanced cardiac magnetic resonance. / Fieno, David S.; Thomson, Louise E J; Slomka, Piotr; Abidov, Aiden; Friedman, John D.; Germano, Guido; Berman, Daniel S.

In: Journal of Nuclear Cardiology, Vol. 14, No. 1, 01.2007, p. 59-67.

Research output: Contribution to journalArticle

@article{93a17a9be0864cdc9b49fc68dd93d5f8,
title = "Quantitation of infarct size in patients with chronic coronary artery disease using rest-redistribution Tl-201 myocardial perfusion SPECT: Correlation with contrast-enhanced cardiac magnetic resonance",
abstract = "Background: Rest and rest-redistribution thallium 201 myocardial perfusion single photon emission computed tomography (SPECT) (MPS) has been incompletely validated in patients for determination of the total amount of scarred myocardium. We sought to determine whether rest or redistribution Tl-201 MPS provides an accurate determination of infarct size as defined by delayed contrast-enhanced cardiac magnetic resonance (CMR). Methods and Results: We studied patients (n = 44) with chronic coronary artery disease referred for rest-redistribution Tl-201 MPS, who were also studied by contrast-enhanced CMR within 3 ± 4 days. Patients were considered retrospectively based on a series of patients referred for clinically indicated MPS. Defect size, as a percent of left ventricular mass ({\%} LV), was determined by quantitative perfusion SPECT (QPS) and compared with the volume of delayed hyperenhancement on contrast-enhanced CMR, normalized to LV mass. Infarct size varied from 0{\%} to 43{\%} LV. Rest QPS defect size correlated with the amount of nonviable myocardium assessed by contrast-enhanced CMR (r = 0.76; mean difference, 4.3{\%} ± 8.0{\%} LV). When delayed thallium data were considered, redistribution QPS was superior to rest QPS for determination of infarct size (redistribution r = 0.90; mean difference, 2.4{\%} ± 5.2{\%} LV; P = .03 vs rest). Conclusion: Rest-redistribution Tl-201 MPS provides a more accurate measurement of total infarct size than rest-only Tl-201 MPS and correlates with contrast-enhanced CMR.",
keywords = "Contrast-enhanced cardiac magnetic resonance, myocardial infarction, rest-redistribution, single photon emission computed tomography, thallium 201",
author = "Fieno, {David S.} and Thomson, {Louise E J} and Piotr Slomka and Aiden Abidov and Friedman, {John D.} and Guido Germano and Berman, {Daniel S.}",
year = "2007",
month = "1",
doi = "10.1016/j.nuclcard.2006.08.019",
language = "English (US)",
volume = "14",
pages = "59--67",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Quantitation of infarct size in patients with chronic coronary artery disease using rest-redistribution Tl-201 myocardial perfusion SPECT

T2 - Correlation with contrast-enhanced cardiac magnetic resonance

AU - Fieno, David S.

AU - Thomson, Louise E J

AU - Slomka, Piotr

AU - Abidov, Aiden

AU - Friedman, John D.

AU - Germano, Guido

AU - Berman, Daniel S.

PY - 2007/1

Y1 - 2007/1

N2 - Background: Rest and rest-redistribution thallium 201 myocardial perfusion single photon emission computed tomography (SPECT) (MPS) has been incompletely validated in patients for determination of the total amount of scarred myocardium. We sought to determine whether rest or redistribution Tl-201 MPS provides an accurate determination of infarct size as defined by delayed contrast-enhanced cardiac magnetic resonance (CMR). Methods and Results: We studied patients (n = 44) with chronic coronary artery disease referred for rest-redistribution Tl-201 MPS, who were also studied by contrast-enhanced CMR within 3 ± 4 days. Patients were considered retrospectively based on a series of patients referred for clinically indicated MPS. Defect size, as a percent of left ventricular mass (% LV), was determined by quantitative perfusion SPECT (QPS) and compared with the volume of delayed hyperenhancement on contrast-enhanced CMR, normalized to LV mass. Infarct size varied from 0% to 43% LV. Rest QPS defect size correlated with the amount of nonviable myocardium assessed by contrast-enhanced CMR (r = 0.76; mean difference, 4.3% ± 8.0% LV). When delayed thallium data were considered, redistribution QPS was superior to rest QPS for determination of infarct size (redistribution r = 0.90; mean difference, 2.4% ± 5.2% LV; P = .03 vs rest). Conclusion: Rest-redistribution Tl-201 MPS provides a more accurate measurement of total infarct size than rest-only Tl-201 MPS and correlates with contrast-enhanced CMR.

AB - Background: Rest and rest-redistribution thallium 201 myocardial perfusion single photon emission computed tomography (SPECT) (MPS) has been incompletely validated in patients for determination of the total amount of scarred myocardium. We sought to determine whether rest or redistribution Tl-201 MPS provides an accurate determination of infarct size as defined by delayed contrast-enhanced cardiac magnetic resonance (CMR). Methods and Results: We studied patients (n = 44) with chronic coronary artery disease referred for rest-redistribution Tl-201 MPS, who were also studied by contrast-enhanced CMR within 3 ± 4 days. Patients were considered retrospectively based on a series of patients referred for clinically indicated MPS. Defect size, as a percent of left ventricular mass (% LV), was determined by quantitative perfusion SPECT (QPS) and compared with the volume of delayed hyperenhancement on contrast-enhanced CMR, normalized to LV mass. Infarct size varied from 0% to 43% LV. Rest QPS defect size correlated with the amount of nonviable myocardium assessed by contrast-enhanced CMR (r = 0.76; mean difference, 4.3% ± 8.0% LV). When delayed thallium data were considered, redistribution QPS was superior to rest QPS for determination of infarct size (redistribution r = 0.90; mean difference, 2.4% ± 5.2% LV; P = .03 vs rest). Conclusion: Rest-redistribution Tl-201 MPS provides a more accurate measurement of total infarct size than rest-only Tl-201 MPS and correlates with contrast-enhanced CMR.

KW - Contrast-enhanced cardiac magnetic resonance

KW - myocardial infarction

KW - rest-redistribution

KW - single photon emission computed tomography

KW - thallium 201

UR - http://www.scopus.com/inward/record.url?scp=33846577773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846577773&partnerID=8YFLogxK

U2 - 10.1016/j.nuclcard.2006.08.019

DO - 10.1016/j.nuclcard.2006.08.019

M3 - Article

C2 - 17276307

AN - SCOPUS:33846577773

VL - 14

SP - 59

EP - 67

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 1

ER -