Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease

Rohan S. Virgincar, Zackary I. Cleveland, S. Sivaram Kaushik, Matthew S. Freeman, John Nouls, Gary P. Cofer, Santiago Martinez-Jimenez, Mu He, Monica Kraft, Jan Wolber, H. Page Mcadams, Bastiaan Driehuys

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

In this study, hyperpolarized 129Xe MR ventilation and 1H anatomical images were obtained from three subject groups: young healthy volunteers (HVs), subjects with chronic obstructive pulmonary disease (COPD) and age-matched controls (AMCs). Ventilation images were quantified by two methods: an expert reader-based ventilation defect score percentage (VDS%) and a semi-automated segmentation-based ventilation defect percentage (VDP). Reader-based values were assigned by two experienced radiologists and resolved by consensus. In the semi-automated analysis, 1H anatomical images and 129Xe ventilation images were both segmented following registration to obtain the thoracic cavity volume and ventilated volume, respectively, which were then expressed as a ratio to obtain the VDP. Ventilation images were also characterized by generating signal intensity histograms from voxels within the thoracic cavity volume, and heterogeneity was analyzed using the coefficient of variation (CV). The reader-based VDS% correlated strongly with the semi-automatically generated VDP (r=0.97, p<0.0001) and with CV (r=0.82, p<0.0001). Both 129Xe ventilation defect scoring metrics readily separated the three groups from one another and correlated significantly with the forced expiratory volume in 1s (FEV1) (VDS%: r=-0.78, p=0.0002; VDP: r=-0.79, p=0.0003; CV: r=-0.66, p=0.0059) and other pulmonary function tests. In the healthy subject groups (HVs and AMCs), the prevalence of ventilation defects also increased with age (VDS%: r=0.61, p=0.0002; VDP: r=0.63, p=0.0002). Moreover, ventilation histograms and their associated CVs distinguished between subjects with COPD with similar ventilation defect scores, but visibly different ventilation patterns.

Original languageEnglish (US)
Pages (from-to)424-435
Number of pages12
JournalNMR in biomedicine
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2013

Keywords

  • COPD
  • Coefficient of variation
  • Defect
  • Hyperpolarized
  • MRI
  • Segmentation
  • Ventilation
  • Xe

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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  • Cite this

    Virgincar, R. S., Cleveland, Z. I., Sivaram Kaushik, S., Freeman, M. S., Nouls, J., Cofer, G. P., Martinez-Jimenez, S., He, M., Kraft, M., Wolber, J., Page Mcadams, H., & Driehuys, B. (2013). Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. NMR in biomedicine, 26(4), 424-435. https://doi.org/10.1002/nbm.2880