Quantitative analysis of portal tract infiltrate allows for accurate determination of hepatic allograft rejection

Howard Sankary, Preston Foster, Ken Novich, Marylin Ashmann, A. Bhattacharyya, James Coleman, James Williams

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Changes in the qualitative character of the portal tract infiltrate of hepatic allografts can influence the diagnosis of acute rejection. Since qualitative data rely on subjective findings, the aim of this study was to perform a quantitative analysis of portal tract infiltrates to improve the accuracy of the diagnosis of acute rejection. A total of 431 serial hepatic biopsies in 58 consecutive adult patients were obtained. The average number of eosinophils, neutrophils, and lymphocytes in each portal tract were counted. The area of each portal tract was determined using an optical micrometer. Rejection was confirmed by an independent investigator using both clinical and histologic criteria. Using a backward stepwise logistic regression analysis, we found that eosinophils were the only variable predictive of rejection. Using this model, the probability of having rejection on a single biopsy can be determined with greater than 90% accuracy.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalThe American Journal of Surgery
Volume161
Issue number1
DOIs
StatePublished - Jan 1991
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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