Quantitative aspects of lung pathology in cystic fibrosis

Richard E Sobonya, L. M. Taussig

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The lungs of 9 patients with cystic fibrosis were studied by morphometric techniques to determine the amount of bronchiectasis, emphysema, pneumonia, bronchial gland enlargement, and small airways narrowing and density. The severity of these processes, which should account for the clinical picture of air-flow limitation in these patients, varied greatly among patients of different ages. Bronchiectasis was present in all children, but the amount of bronchiectasis did not appear to increase with age. Mild destructive emphysema was seen only in adults, but many younger patients had overinflation without destructive emphysema, as recognized by increased mean linear intercept (interalveolar distance). Despite clinical evidence of mucous hypersecretion, bronchial gland enlargement was present only in some patients. The youngest patient showed normal small airways, but children and younger teenagers tended to have dilated small airways. Older teenagers and adults predominantly had stenosis of small airways. Varying patterns of pulmonary pathology are seen in cystic fibrosis and may be related to rapidity of progression of disease.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume134
Issue number2
StatePublished - 1986

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Cystic Fibrosis
Pathology
Lung
Bronchiectasis
Emphysema
Bronchopneumonia
Disease Progression
Young Adult
Pathologic Constriction
Air

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Quantitative aspects of lung pathology in cystic fibrosis. / Sobonya, Richard E; Taussig, L. M.

In: American Review of Respiratory Disease, Vol. 134, No. 2, 1986, p. 290-295.

Research output: Contribution to journalArticle

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