Quantitative methods for assessing a synergistic or potentiated genotoxic response

Walter W. Piegorsch, Barry H. Margolin

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalMutation Research/Environmental Mutagenesis and Related Subjects
Volume216
Issue number1
DOIs
StatePublished - Feb 1989
Externally publishedYes

Keywords

  • Binary data
  • Chromosome aberrations
  • Factorial experiments
  • Fluctuation assay
  • Interaction
  • Simple independent action
  • Simple similar action

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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