Quantitative pathology of coccidioidomycosis in acquired immunodeficiency syndrome

Anna R. Graham, Richard E. Sobonya, Danetta A. Bronnimann, John N. Galgiani

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

This study examines the laboratory aspects of diagnosis of coccidioidomycosisin 11 patients with acquired immunodeficiency syndrome (AIDS) and the qualitative and quantitative differences between host responses of AIDS and non-AIDS patients who died with disseminated coccidioidomycosis. Material obtained at bronchoscopy confirmed the diagnosis of pulmonary coccidioidomycosis in 67% (6/9) of the patients. Patients with AIDS had a generally poor granulomatous response and statistically significantly increased numbers of spherules in lung tissue compared with non-AIDS patients. Neither antifungal therapy nor duration of clinical disease influenced the number of organisms present. The findings suggest a parallel betweeN AIDS-associated coccidioidomycosis and other granulomatous diseases such as leprosy and schistosomiasis, in which the type of granuloma formation and organism numbers are influenced by the T-lymphocyte milieu.

Original languageEnglish (US)
Pages (from-to)800-806
Number of pages7
JournalHuman pathology
Volume19
Issue number7
DOIs
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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