Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity

A. M. Hays, R. L. Keller, A. Gmitro, M. Alpbach, M. T. Padilla, M. P. Balagtas, M. O'Donnell, M. L. Witten

Research output: Contribution to journalArticle

Abstract

A magnetic resonance (MR) angiographic technique for noninvasive measurement of flow in the inferior vena cava was used to study flow changes in a HDT model of simulated microgravity. Quantitative phase contrast images of flow within the vena cava were obtained before (n=12) and after (n=12) a two week HDT protocol. Regional blood flow was determined by converting the intensity at the respective pixels into a corresponding flow. Average values for flow determined with MR angiography were 3.52 (S.E.M=0.05) mm3/sec before and 5.24 (S.E.M=0.05) mm3/sec after exposure to the HDT protocol. Post two week HDT flow increased 67% over the pre-HDT value. Using a paired t-test, a significant difference was found between flow values in the pre and post-HDT groups (p<0.004). We speculate that the changes in vena cava blood flow due to 45°. HDT may contribute to the overall changes observed in the cardiovascular System.

Original languageEnglish (US)
Pages (from-to)A242
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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    Hays, A. M., Keller, R. L., Gmitro, A., Alpbach, M., Padilla, M. T., Balagtas, M. P., O'Donnell, M., & Witten, M. L. (1997). Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity. FASEB Journal, 11(3), A242.