Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity

A. M. Hays, R. L. Keller, Arthur F Gmitro, M. Alpbach, M. T. Padilla, M. P. Balagtas, M. O'Donnell, M. L. Witten

Research output: Contribution to journalArticle

Abstract

A magnetic resonance (MR) angiographic technique for noninvasive measurement of flow in the inferior vena cava was used to study flow changes in a HDT model of simulated microgravity. Quantitative phase contrast images of flow within the vena cava were obtained before (n=12) and after (n=12) a two week HDT protocol. Regional blood flow was determined by converting the intensity at the respective pixels into a corresponding flow. Average values for flow determined with MR angiography were 3.52 (S.E.M=0.05) mm3/sec before and 5.24 (S.E.M=0.05) mm3/sec after exposure to the HDT protocol. Post two week HDT flow increased 67% over the pre-HDT value. Using a paired t-test, a significant difference was found between flow values in the pre and post-HDT groups (p<0.004). We speculate that the changes in vena cava blood flow due to 45°. HDT may contribute to the overall changes observed in the cardiovascular System.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

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Head-Down Tilt
microgravity
Weightlessness
vena cava
Venae Cavae
Microgravity
Magnetic resonance
Rats
Blood
Cardiovascular system
Scanning electron microscopy
Angiography
rats
Pixels
blood flow
inferior vena cava
cardiovascular system
Magnetic Resonance Angiography
Regional Blood Flow
Inferior Vena Cava

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Hays, A. M., Keller, R. L., Gmitro, A. F., Alpbach, M., Padilla, M. T., Balagtas, M. P., ... Witten, M. L. (1997). Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity. FASEB Journal, 11(3).

Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity. / Hays, A. M.; Keller, R. L.; Gmitro, Arthur F; Alpbach, M.; Padilla, M. T.; Balagtas, M. P.; O'Donnell, M.; Witten, M. L.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Hays, AM, Keller, RL, Gmitro, AF, Alpbach, M, Padilla, MT, Balagtas, MP, O'Donnell, M & Witten, ML 1997, 'Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity', FASEB Journal, vol. 11, no. 3.
Hays, A. M. ; Keller, R. L. ; Gmitro, Arthur F ; Alpbach, M. ; Padilla, M. T. ; Balagtas, M. P. ; O'Donnell, M. ; Witten, M. L. / Quantitative phase contrast images of flow within the rat vena cava in a 45° rat head down tilt (HDT) model of simulated microgravity. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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AU - Balagtas, M. P.

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