Quantitative phase contrast images to quantitate flow in a rat model of microgravity

Allison M. Hays, Rachel L. Keller, Arthur F Gmitro, Maria I. Alpbach, K. R. Sridhar, Madel P. Balagtas, Mark L. Witten

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A magnetic resonance angiographic (MRA) technique for noninvasive measurement of flow in the inferior vena cava (IVC) was used to study blood flow changes in a simulated microgravity model. Microgravity was simulated in adult male Fischer 344 rats (n = 12, with each rat acting as its own control) using a tail harness to elevate the hindquarters, producing a non-weight bearing hindlimb (NWH) model. Quantitative phase contrast images of flow within the IVC were obtained initially and after a 2-week NWH protocol. Inferior vena cava blood flow was determined by converting the intensity at the respective magnetic resonance pixels into a corresponding flow by Doppler techniques. Average values for flow determined with MR angiography were 351.8 (SEM = 49) mm3 · s-1 initially and 524.5 (SEM = 46) mm3 · s-1 after exposure to 2 weeks of the NWH protocol. Post 2-week NWH flow increased 49.1% over the initial NWH value. Using a paired t-test, a significant difference was found between the rats' IVC flow values in the initial and post-NWH groups (p < 0.004). The changes in IVC blood flow due to 45°NWH may contribute to the overall changes observed in the cardiovascular system during simulated microgravity.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalAviation Space and Environmental Medicine
Volume70
Issue number3 I
StatePublished - Mar 1999

Fingerprint

Bearings (structural)
Weightlessness
Microgravity
Hindlimb
Inferior Vena Cava
Rats
Blood
Magnetic resonance
Magnetic Resonance Spectroscopy
Cardiovascular system
Scanning electron microscopy
Angiography
Inbred F344 Rats
Cardiovascular System
Tail
Pixels

Keywords

  • Magnetic resonance imaging
  • Microgravity
  • Non-weight bearing hind-limb model

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution
  • Medicine(all)

Cite this

Hays, A. M., Keller, R. L., Gmitro, A. F., Alpbach, M. I., Sridhar, K. R., Balagtas, M. P., & Witten, M. L. (1999). Quantitative phase contrast images to quantitate flow in a rat model of microgravity. Aviation Space and Environmental Medicine, 70(3 I), 225-229.

Quantitative phase contrast images to quantitate flow in a rat model of microgravity. / Hays, Allison M.; Keller, Rachel L.; Gmitro, Arthur F; Alpbach, Maria I.; Sridhar, K. R.; Balagtas, Madel P.; Witten, Mark L.

In: Aviation Space and Environmental Medicine, Vol. 70, No. 3 I, 03.1999, p. 225-229.

Research output: Contribution to journalArticle

Hays, AM, Keller, RL, Gmitro, AF, Alpbach, MI, Sridhar, KR, Balagtas, MP & Witten, ML 1999, 'Quantitative phase contrast images to quantitate flow in a rat model of microgravity', Aviation Space and Environmental Medicine, vol. 70, no. 3 I, pp. 225-229.
Hays AM, Keller RL, Gmitro AF, Alpbach MI, Sridhar KR, Balagtas MP et al. Quantitative phase contrast images to quantitate flow in a rat model of microgravity. Aviation Space and Environmental Medicine. 1999 Mar;70(3 I):225-229.
Hays, Allison M. ; Keller, Rachel L. ; Gmitro, Arthur F ; Alpbach, Maria I. ; Sridhar, K. R. ; Balagtas, Madel P. ; Witten, Mark L. / Quantitative phase contrast images to quantitate flow in a rat model of microgravity. In: Aviation Space and Environmental Medicine. 1999 ; Vol. 70, No. 3 I. pp. 225-229.
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