Quantitative specific binding of breast cancer cells in an antibody-functionalized microchamber array

X. J. Zheng, L. S.L. Cheung, L. Wang, J. Schroeder, R. L. Heimark, J. C. Baygents, R. Guzman, Y. Zohar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The system performance of an antibody-functionalized microchamber array, developed for selectively binding target cancer cells, is quantitatively characterized. The devices are designed to allow accurate counting of loaded and captured cells from heterogeneous suspensions. Specific interaction between cancer cell receptors and immobilized surface ligands has been demonstrated under static conditions. Performance measures such as specificity, sensitivity and accuracy are uniquely defined and experimentally evaluated. Several cell mixtures have been tested, and the quantitative system performance criteria are reported as a function of cell concentrations in the tested suspensions. These criteria provide a critical quantitative basis for a comparison among different systems aimed at selectively isolating target bio-species from complex mixtures.

Original languageEnglish (US)
Title of host publicationMEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest
Pages939-942
Number of pages4
DOIs
StatePublished - Jun 1 2010
Event23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010 - Hong Kong, China
Duration: Jan 24 2010Jan 28 2010

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010
CountryChina
CityHong Kong
Period1/24/101/28/10

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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    Zheng, X. J., Cheung, L. S. L., Wang, L., Schroeder, J., Heimark, R. L., Baygents, J. C., Guzman, R., & Zohar, Y. (2010). Quantitative specific binding of breast cancer cells in an antibody-functionalized microchamber array. In MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest (pp. 939-942). [5442362] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2010.5442362