A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgpl20 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gpl20.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Jun 18 2001|
- Fluorescence spectroscopy
- Structure-activity relationships
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