Quantitative studies of binding between synthetic galactosyl ceramide analogues and HIV-1 gp120 at planar membrane surfaces

Yingmei Gu, Rachel LaBell, David F. O'Brien, S. Scott Saavedra

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgpl20 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gpl20.

Original languageEnglish (US)
Pages (from-to)2320-2322
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number12
DOIs
StatePublished - Jun 18 2001

Keywords

  • Fluorescence spectroscopy
  • Glycoproteins
  • HIV
  • Sphingolipids
  • Structure-activity relationships

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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