Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

Béatrice Hauss-Wegrzyniak, Jean-Philippe Galons, Gary L. Wenk

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalExperimental Neurology
Volume165
Issue number2
DOIs
StatePublished - 2000

Fingerprint

Temporal Lobe
Magnetic Resonance Imaging
Alzheimer Disease
Brain
Fourth Ventricle
Lateral Ventricles
Encephalitis
Neurodegenerative Diseases
Lipopolysaccharides
Hippocampus

Keywords

  • Alzheimer's disease
  • Brain inflammation
  • Hippocampus
  • Magnetic resonance imaging
  • Rats

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation. / Hauss-Wegrzyniak, Béatrice; Galons, Jean-Philippe; Wenk, Gary L.

In: Experimental Neurology, Vol. 165, No. 2, 2000, p. 347-354.

Research output: Contribution to journalArticle

@article{e92bcf759e30400882e8b95a07bb5374,
title = "Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation",
abstract = "Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.",
keywords = "Alzheimer's disease, Brain inflammation, Hippocampus, Magnetic resonance imaging, Rats",
author = "B{\'e}atrice Hauss-Wegrzyniak and Jean-Philippe Galons and Wenk, {Gary L.}",
year = "2000",
doi = "10.1006/exnr.2000.7469",
language = "English (US)",
volume = "165",
pages = "347--354",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

AU - Hauss-Wegrzyniak, Béatrice

AU - Galons, Jean-Philippe

AU - Wenk, Gary L.

PY - 2000

Y1 - 2000

N2 - Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.

AB - Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.

KW - Alzheimer's disease

KW - Brain inflammation

KW - Hippocampus

KW - Magnetic resonance imaging

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=0033798094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033798094&partnerID=8YFLogxK

U2 - 10.1006/exnr.2000.7469

DO - 10.1006/exnr.2000.7469

M3 - Article

VL - 165

SP - 347

EP - 354

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 2

ER -