Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

Béatrice Hauss-Wegrzyniak, Jean Philippe Galons, Gary L. Wenk

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalExperimental Neurology
Volume165
Issue number2
DOIs
StatePublished - Jan 1 2000

Keywords

  • Alzheimer's disease
  • Brain inflammation
  • Hippocampus
  • Magnetic resonance imaging
  • Rats

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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